Design, Synthesis, and Anticancer Activity of 1,2,3-Triazole Linked 1,2-Isoxazole-imidazo[4,5-b]pyridine Derivatives
- Authors: Murthy I.S.1, Sreenivasulu R.2, Alluraiah G.1, Ramesh Raju R.1
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Affiliations:
- Department of Chemistry
- Department of Chemistry, University College of Engineering (Autonomous)
- Issue: Vol 89, No 8 (2019)
- Pages: 1718-1723
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223053
- DOI: https://doi.org/10.1134/S1070363219080279
- ID: 223053
Cite item
Abstract
A series of novel 1,2-isoxazole-pyridobenzimidazole is synthesized. Structures of the products are supported by 1H and 13C NMR, and mass spectra. All compounds have been tested for their anticancer activity towards four human cancer cell lines including MCF-7 (breast cancer), A549 (lung cancer), Colon-205 (colon cancer), and A2780 (ovarian cancer). Etoposide was used as a standard drug. The determined IC50 values range from 0.01±0.003 to 23.7±3.72 µM. Among all compounds, six products exhibit the most significant activities.
About the authors
I. S. Murthy
Department of Chemistry
Email: rrraju1@gmail.com
India, Nagarjuna Nagar, Andhra Pradesh, 522510
R. Sreenivasulu
Department of Chemistry, University College of Engineering (Autonomous)
Email: rrraju1@gmail.com
India, Kakinada, Andhra Pradesh, 533003
G. Alluraiah
Department of Chemistry
Email: rrraju1@gmail.com
India, Giddalur, Andhra Pradesh, 523357
R. Ramesh Raju
Department of Chemistry
Author for correspondence.
Email: rrraju1@gmail.com
India, Nagarjuna Nagar, Andhra Pradesh, 522510