Design, Synthesis, and Anticancer Activity of 1,2,3-Triazole Linked 1,2-Isoxazole-imidazo[4,5-b]pyridine Derivatives
- Авторлар: Murthy I.1, Sreenivasulu R.2, Alluraiah G.1, Ramesh Raju R.1
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Мекемелер:
- Department of Chemistry
- Department of Chemistry, University College of Engineering (Autonomous)
- Шығарылым: Том 89, № 8 (2019)
- Беттер: 1718-1723
- Бөлім: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223053
- DOI: https://doi.org/10.1134/S1070363219080279
- ID: 223053
Дәйексөз келтіру
Аннотация
A series of novel 1,2-isoxazole-pyridobenzimidazole is synthesized. Structures of the products are supported by 1H and 13C NMR, and mass spectra. All compounds have been tested for their anticancer activity towards four human cancer cell lines including MCF-7 (breast cancer), A549 (lung cancer), Colon-205 (colon cancer), and A2780 (ovarian cancer). Etoposide was used as a standard drug. The determined IC50 values range from 0.01±0.003 to 23.7±3.72 µM. Among all compounds, six products exhibit the most significant activities.
Авторлар туралы
I. Murthy
Department of Chemistry
Email: rrraju1@gmail.com
Үндістан, Nagarjuna Nagar, Andhra Pradesh, 522510
R. Sreenivasulu
Department of Chemistry, University College of Engineering (Autonomous)
Email: rrraju1@gmail.com
Үндістан, Kakinada, Andhra Pradesh, 533003
G. Alluraiah
Department of Chemistry
Email: rrraju1@gmail.com
Үндістан, Giddalur, Andhra Pradesh, 523357
R. Ramesh Raju
Department of Chemistry
Хат алмасуға жауапты Автор.
Email: rrraju1@gmail.com
Үндістан, Nagarjuna Nagar, Andhra Pradesh, 522510