Design, Synthesis, and Anticancer Activity of 1,2,3-Triazole Linked 1,2-Isoxazole-imidazo[4,5-b]pyridine Derivatives
- 作者: Murthy I.1, Sreenivasulu R.2, Alluraiah G.1, Ramesh Raju R.1
-
隶属关系:
- Department of Chemistry
- Department of Chemistry, University College of Engineering (Autonomous)
- 期: 卷 89, 编号 8 (2019)
- 页面: 1718-1723
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223053
- DOI: https://doi.org/10.1134/S1070363219080279
- ID: 223053
如何引用文章
详细
A series of novel 1,2-isoxazole-pyridobenzimidazole is synthesized. Structures of the products are supported by 1H and 13C NMR, and mass spectra. All compounds have been tested for their anticancer activity towards four human cancer cell lines including MCF-7 (breast cancer), A549 (lung cancer), Colon-205 (colon cancer), and A2780 (ovarian cancer). Etoposide was used as a standard drug. The determined IC50 values range from 0.01±0.003 to 23.7±3.72 µM. Among all compounds, six products exhibit the most significant activities.
作者简介
I. Murthy
Department of Chemistry
Email: rrraju1@gmail.com
印度, Nagarjuna Nagar, Andhra Pradesh, 522510
R. Sreenivasulu
Department of Chemistry, University College of Engineering (Autonomous)
Email: rrraju1@gmail.com
印度, Kakinada, Andhra Pradesh, 533003
G. Alluraiah
Department of Chemistry
Email: rrraju1@gmail.com
印度, Giddalur, Andhra Pradesh, 523357
R. Ramesh Raju
Department of Chemistry
编辑信件的主要联系方式.
Email: rrraju1@gmail.com
印度, Nagarjuna Nagar, Andhra Pradesh, 522510