Design, Synthesis, and Anticancer Activity of 1,2,3-Triazole Linked 1,2-Isoxazole-imidazo[4,5-b]pyridine Derivatives
- Авторы: Murthy I.1, Sreenivasulu R.2, Alluraiah G.1, Ramesh Raju R.1
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Учреждения:
- Department of Chemistry
- Department of Chemistry, University College of Engineering (Autonomous)
- Выпуск: Том 89, № 8 (2019)
- Страницы: 1718-1723
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223053
- DOI: https://doi.org/10.1134/S1070363219080279
- ID: 223053
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Аннотация
A series of novel 1,2-isoxazole-pyridobenzimidazole is synthesized. Structures of the products are supported by 1H and 13C NMR, and mass spectra. All compounds have been tested for their anticancer activity towards four human cancer cell lines including MCF-7 (breast cancer), A549 (lung cancer), Colon-205 (colon cancer), and A2780 (ovarian cancer). Etoposide was used as a standard drug. The determined IC50 values range from 0.01±0.003 to 23.7±3.72 µM. Among all compounds, six products exhibit the most significant activities.
Об авторах
I. Murthy
Department of Chemistry
Email: rrraju1@gmail.com
Индия, Nagarjuna Nagar, Andhra Pradesh, 522510
R. Sreenivasulu
Department of Chemistry, University College of Engineering (Autonomous)
Email: rrraju1@gmail.com
Индия, Kakinada, Andhra Pradesh, 533003
G. Alluraiah
Department of Chemistry
Email: rrraju1@gmail.com
Индия, Giddalur, Andhra Pradesh, 523357
R. Ramesh Raju
Department of Chemistry
Автор, ответственный за переписку.
Email: rrraju1@gmail.com
Индия, Nagarjuna Nagar, Andhra Pradesh, 522510