An Efficient Synthesis and Antimicrobial Activity of 5-{2-[(1-Aryl-1H-1,2,3-triazol-4-yl)methoxy]-5-bromophenyl}isoxazoles
- Authors: Thotla K.1, Giri Noole V.1, Kedika B.1, Reddy K.1
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Affiliations:
- Department of Chemistry
- Issue: Vol 89, No 4 (2019)
- Pages: 789-793
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222872
- DOI: https://doi.org/10.1134/S1070363219040248
- ID: 222872
Cite item
Abstract
A novel series of 1,2,3-triazolyl isoxazole derivatives is synthesized from the corresponding propargylated isoxazoles and a number of aryl azides by the Click reaction. The highest yields of the reaction are achieved in the presence of copper sulphate pentahydrate and sodium ascorbate, and using DMF:water (2:1) as a medium. The compounds structures are elucidated from various spectral data. Antimicrobial activity tests of the title compounds demonstrate their moderate to good results compared to the standard.
About the authors
K. Thotla
Department of Chemistry
Email: krreddych@gmail.com
India, Hyderabad, 500007
V. Giri Noole
Department of Chemistry
Email: krreddych@gmail.com
India, Hyderabad, 500007
B. Kedika
Department of Chemistry
Email: krreddych@gmail.com
India, Hyderabad, 500007
K. Reddy
Department of Chemistry
Author for correspondence.
Email: krreddych@gmail.com
India, Hyderabad, 500007