An Efficient Synthesis and Antimicrobial Activity of 5-{2-[(1-Aryl-1H-1,2,3-triazol-4-yl)methoxy]-5-bromophenyl}isoxazoles
- Авторы: Thotla K.1, Giri Noole V.1, Kedika B.1, Reddy K.1
-
Учреждения:
- Department of Chemistry
- Выпуск: Том 89, № 4 (2019)
- Страницы: 789-793
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222872
- DOI: https://doi.org/10.1134/S1070363219040248
- ID: 222872
Цитировать
Аннотация
A novel series of 1,2,3-triazolyl isoxazole derivatives is synthesized from the corresponding propargylated isoxazoles and a number of aryl azides by the Click reaction. The highest yields of the reaction are achieved in the presence of copper sulphate pentahydrate and sodium ascorbate, and using DMF:water (2:1) as a medium. The compounds structures are elucidated from various spectral data. Antimicrobial activity tests of the title compounds demonstrate their moderate to good results compared to the standard.
Об авторах
K. Thotla
Department of Chemistry
Email: krreddych@gmail.com
Индия, Hyderabad, 500007
V. Giri Noole
Department of Chemistry
Email: krreddych@gmail.com
Индия, Hyderabad, 500007
B. Kedika
Department of Chemistry
Email: krreddych@gmail.com
Индия, Hyderabad, 500007
K. Reddy
Department of Chemistry
Автор, ответственный за переписку.
Email: krreddych@gmail.com
Индия, Hyderabad, 500007