An Improved Procedure for the Gas Chromatography–Tandem Mass Spectrometry Detection of the Globin Adduct of Sulfur Mustard
- 作者: Koryagina N.1, Shachneva M.1, Ukolov A.1, Savel’eva E.1, Khlebnikova N.1, Radilov A.1
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隶属关系:
- Research Institute of Hygiene, Occupational Pathology, and Human Ecology, Federal Medical-Biological Agency of Russia
- 期: 卷 73, 编号 13 (2018)
- 页面: 1269-1274
- 栏目: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/182910
- DOI: https://doi.org/10.1134/S1061934818130087
- ID: 182910
如何引用文章
详细
Features of the electron and chemical ionization mass spectra of derivatives of N-[2-[(hydroxyethyl)thio]ethyl]-DL-valine (НЕТЕ-Val)—a biomarker of sulfur mustard—recorded by GC–MS and GC–MS/MS are studied. The retention indices of the studied derivatives were measured. An optimized procedure of the GC–MS/MS (MRM mode) identification of НЕТЕ-Val was tested in the analysis of donor blood samples in vitro exposed to sulfur mustard. The linear range of the detector was from 10 to 100 ng mL–1, and the limit of detection for sulfur mustard was 10 ng mL–1.
作者简介
N. Koryagina
Research Institute of Hygiene, Occupational Pathology, and Human Ecology, Federal Medical-Biological Agencyof Russia
编辑信件的主要联系方式.
Email: koryagina@rihophe.ru
俄罗斯联邦, Kuzmolovsky, Vsevolozhsk district, Leningrad oblast, 188663
M. Shachneva
Research Institute of Hygiene, Occupational Pathology, and Human Ecology, Federal Medical-Biological Agencyof Russia
Email: koryagina@rihophe.ru
俄罗斯联邦, Kuzmolovsky, Vsevolozhsk district, Leningrad oblast, 188663
A. Ukolov
Research Institute of Hygiene, Occupational Pathology, and Human Ecology, Federal Medical-Biological Agencyof Russia
Email: koryagina@rihophe.ru
俄罗斯联邦, Kuzmolovsky, Vsevolozhsk district, Leningrad oblast, 188663
E. Savel’eva
Research Institute of Hygiene, Occupational Pathology, and Human Ecology, Federal Medical-Biological Agencyof Russia
Email: koryagina@rihophe.ru
俄罗斯联邦, Kuzmolovsky, Vsevolozhsk district, Leningrad oblast, 188663
N. Khlebnikova
Research Institute of Hygiene, Occupational Pathology, and Human Ecology, Federal Medical-Biological Agencyof Russia
Email: koryagina@rihophe.ru
俄罗斯联邦, Kuzmolovsky, Vsevolozhsk district, Leningrad oblast, 188663
A. Radilov
Research Institute of Hygiene, Occupational Pathology, and Human Ecology, Federal Medical-Biological Agencyof Russia
Email: koryagina@rihophe.ru
俄罗斯联邦, Kuzmolovsky, Vsevolozhsk district, Leningrad oblast, 188663