An Improved Procedure for the Gas Chromatography–Tandem Mass Spectrometry Detection of the Globin Adduct of Sulfur Mustard
- Authors: Koryagina N.L.1, Shachneva M.D.1, Ukolov A.I.1, Savel’eva E.I.1, Khlebnikova N.S.1, Radilov A.S.1
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Affiliations:
- Research Institute of Hygiene, Occupational Pathology, and Human Ecology, Federal Medical-Biological Agency of Russia
- Issue: Vol 73, No 13 (2018)
- Pages: 1269-1274
- Section: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/182910
- DOI: https://doi.org/10.1134/S1061934818130087
- ID: 182910
Cite item
Abstract
Features of the electron and chemical ionization mass spectra of derivatives of N-[2-[(hydroxyethyl)thio]ethyl]-DL-valine (НЕТЕ-Val)—a biomarker of sulfur mustard—recorded by GC–MS and GC–MS/MS are studied. The retention indices of the studied derivatives were measured. An optimized procedure of the GC–MS/MS (MRM mode) identification of НЕТЕ-Val was tested in the analysis of donor blood samples in vitro exposed to sulfur mustard. The linear range of the detector was from 10 to 100 ng mL–1, and the limit of detection for sulfur mustard was 10 ng mL–1.
About the authors
N. L. Koryagina
Research Institute of Hygiene, Occupational Pathology, and Human Ecology, Federal Medical-Biological Agencyof Russia
Author for correspondence.
Email: koryagina@rihophe.ru
Russian Federation, Kuzmolovsky, Vsevolozhsk district, Leningrad oblast, 188663
M. D. Shachneva
Research Institute of Hygiene, Occupational Pathology, and Human Ecology, Federal Medical-Biological Agencyof Russia
Email: koryagina@rihophe.ru
Russian Federation, Kuzmolovsky, Vsevolozhsk district, Leningrad oblast, 188663
A. I. Ukolov
Research Institute of Hygiene, Occupational Pathology, and Human Ecology, Federal Medical-Biological Agencyof Russia
Email: koryagina@rihophe.ru
Russian Federation, Kuzmolovsky, Vsevolozhsk district, Leningrad oblast, 188663
E. I. Savel’eva
Research Institute of Hygiene, Occupational Pathology, and Human Ecology, Federal Medical-Biological Agencyof Russia
Email: koryagina@rihophe.ru
Russian Federation, Kuzmolovsky, Vsevolozhsk district, Leningrad oblast, 188663
N. S. Khlebnikova
Research Institute of Hygiene, Occupational Pathology, and Human Ecology, Federal Medical-Biological Agencyof Russia
Email: koryagina@rihophe.ru
Russian Federation, Kuzmolovsky, Vsevolozhsk district, Leningrad oblast, 188663
A. S. Radilov
Research Institute of Hygiene, Occupational Pathology, and Human Ecology, Federal Medical-Biological Agencyof Russia
Email: koryagina@rihophe.ru
Russian Federation, Kuzmolovsky, Vsevolozhsk district, Leningrad oblast, 188663