An Improved Procedure for the Gas Chromatography–Tandem Mass Spectrometry Detection of the Globin Adduct of Sulfur Mustard


Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Тек жазылушылар үшін

Аннотация

Features of the electron and chemical ionization mass spectra of derivatives of N-[2-[(hydroxyethyl)thio]ethyl]-DL-valine (НЕТЕ-Val)—a biomarker of sulfur mustard—recorded by GC–MS and GC–MS/MS are studied. The retention indices of the studied derivatives were measured. An optimized procedure of the GC–MS/MS (MRM mode) identification of НЕТЕ-Val was tested in the analysis of donor blood samples in vitro exposed to sulfur mustard. The linear range of the detector was from 10 to 100 ng mL–1, and the limit of detection for sulfur mustard was 10 ng mL–1.

Авторлар туралы

N. Koryagina

Research Institute of Hygiene, Occupational Pathology, and Human Ecology, Federal Medical-Biological Agency
of Russia

Хат алмасуға жауапты Автор.
Email: koryagina@rihophe.ru
Ресей, Kuzmolovsky, Vsevolozhsk district, Leningrad oblast, 188663

M. Shachneva

Research Institute of Hygiene, Occupational Pathology, and Human Ecology, Federal Medical-Biological Agency
of Russia

Email: koryagina@rihophe.ru
Ресей, Kuzmolovsky, Vsevolozhsk district, Leningrad oblast, 188663

A. Ukolov

Research Institute of Hygiene, Occupational Pathology, and Human Ecology, Federal Medical-Biological Agency
of Russia

Email: koryagina@rihophe.ru
Ресей, Kuzmolovsky, Vsevolozhsk district, Leningrad oblast, 188663

E. Savel’eva

Research Institute of Hygiene, Occupational Pathology, and Human Ecology, Federal Medical-Biological Agency
of Russia

Email: koryagina@rihophe.ru
Ресей, Kuzmolovsky, Vsevolozhsk district, Leningrad oblast, 188663

N. Khlebnikova

Research Institute of Hygiene, Occupational Pathology, and Human Ecology, Federal Medical-Biological Agency
of Russia

Email: koryagina@rihophe.ru
Ресей, Kuzmolovsky, Vsevolozhsk district, Leningrad oblast, 188663

A. Radilov

Research Institute of Hygiene, Occupational Pathology, and Human Ecology, Federal Medical-Biological Agency
of Russia

Email: koryagina@rihophe.ru
Ресей, Kuzmolovsky, Vsevolozhsk district, Leningrad oblast, 188663


© Pleiades Publishing, Inc., 2018

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