An Improved Procedure for the Gas Chromatography–Tandem Mass Spectrometry Detection of the Globin Adduct of Sulfur Mustard
- Авторлар: Koryagina N.1, Shachneva M.1, Ukolov A.1, Savel’eva E.1, Khlebnikova N.1, Radilov A.1
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Мекемелер:
- Research Institute of Hygiene, Occupational Pathology, and Human Ecology, Federal Medical-Biological Agency of Russia
- Шығарылым: Том 73, № 13 (2018)
- Беттер: 1269-1274
- Бөлім: Articles
- URL: https://journals.rcsi.science/1061-9348/article/view/182910
- DOI: https://doi.org/10.1134/S1061934818130087
- ID: 182910
Дәйексөз келтіру
Аннотация
Features of the electron and chemical ionization mass spectra of derivatives of N-[2-[(hydroxyethyl)thio]ethyl]-DL-valine (НЕТЕ-Val)—a biomarker of sulfur mustard—recorded by GC–MS and GC–MS/MS are studied. The retention indices of the studied derivatives were measured. An optimized procedure of the GC–MS/MS (MRM mode) identification of НЕТЕ-Val was tested in the analysis of donor blood samples in vitro exposed to sulfur mustard. The linear range of the detector was from 10 to 100 ng mL–1, and the limit of detection for sulfur mustard was 10 ng mL–1.
Негізгі сөздер
Авторлар туралы
N. Koryagina
Research Institute of Hygiene, Occupational Pathology, and Human Ecology, Federal Medical-Biological Agencyof Russia
Хат алмасуға жауапты Автор.
Email: koryagina@rihophe.ru
Ресей, Kuzmolovsky, Vsevolozhsk district, Leningrad oblast, 188663
M. Shachneva
Research Institute of Hygiene, Occupational Pathology, and Human Ecology, Federal Medical-Biological Agencyof Russia
Email: koryagina@rihophe.ru
Ресей, Kuzmolovsky, Vsevolozhsk district, Leningrad oblast, 188663
A. Ukolov
Research Institute of Hygiene, Occupational Pathology, and Human Ecology, Federal Medical-Biological Agencyof Russia
Email: koryagina@rihophe.ru
Ресей, Kuzmolovsky, Vsevolozhsk district, Leningrad oblast, 188663
E. Savel’eva
Research Institute of Hygiene, Occupational Pathology, and Human Ecology, Federal Medical-Biological Agencyof Russia
Email: koryagina@rihophe.ru
Ресей, Kuzmolovsky, Vsevolozhsk district, Leningrad oblast, 188663
N. Khlebnikova
Research Institute of Hygiene, Occupational Pathology, and Human Ecology, Federal Medical-Biological Agencyof Russia
Email: koryagina@rihophe.ru
Ресей, Kuzmolovsky, Vsevolozhsk district, Leningrad oblast, 188663
A. Radilov
Research Institute of Hygiene, Occupational Pathology, and Human Ecology, Federal Medical-Biological Agencyof Russia
Email: koryagina@rihophe.ru
Ресей, Kuzmolovsky, Vsevolozhsk district, Leningrad oblast, 188663