Methods for determining neurotransmitter metabolism markers for clinical diagnostics
- Authors: Veselova I.A.1,2, Sergeeva E.A.1, Makedonskaya M.I.1,2, Eremina O.E.1,2, Kalmykov S.N.1,2, Shekhovtsova T.N.1
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Affiliations:
- Department of Chemistry
- National Research Centre “Kurchatov Institute”
- Issue: Vol 71, No 12 (2016)
- Pages: 1155-1168
- Section: Reviews
- URL: https://journals.rcsi.science/1061-9348/article/view/182186
- DOI: https://doi.org/10.1134/S1061934816120108
- ID: 182186
Cite item
Abstract
Published data describing the current status and prospects for the development of clinical diagnostics of a number of neurodegenerative and neuroendocrine diseases associated with neurotransmitter balance disorders in a human body are generalized, systematized, and assessed in the review. Characteristics, advantages, and limitations of neuroimaging techniques and different diagnostic methods based on measuring concentrations of protein markers, catecholamines, and their metabolites are discussed. Prospects of the application of optical methods, such as fluorimetry and surface-enhanced Raman spectroscopy, to the development of sensor systems for the diagnosis of these diseases by the concentration of catecholamines and their metabolites in biological fluids are demonstrated.
About the authors
I. A. Veselova
Department of Chemistry; National Research Centre “Kurchatov Institute”
Author for correspondence.
Email: irina.veselova@mail.ru
Russian Federation, Moscow, 119991; Moscow, 123098
E. A. Sergeeva
Department of Chemistry
Email: irina.veselova@mail.ru
Russian Federation, Moscow, 119991
M. I. Makedonskaya
Department of Chemistry; National Research Centre “Kurchatov Institute”
Email: irina.veselova@mail.ru
Russian Federation, Moscow, 119991; Moscow, 123098
O. E. Eremina
Department of Chemistry; National Research Centre “Kurchatov Institute”
Email: irina.veselova@mail.ru
Russian Federation, Moscow, 119991; Moscow, 123098
S. N. Kalmykov
Department of Chemistry; National Research Centre “Kurchatov Institute”
Email: irina.veselova@mail.ru
Russian Federation, Moscow, 119991; Moscow, 123098
T. N. Shekhovtsova
Department of Chemistry
Email: irina.veselova@mail.ru
Russian Federation, Moscow, 119991