Synthesis and Antiglycation Activity of Novel S-Carboxyalkyl Derivatives of 2-Thiouracil

A. A. Spasov; A. N. Geisman; V. A. Kosolapov; D. A. Babkov; A. I. Rashchenko; V. A. Babkova; O. Yu. Zakhar’yashcheva; A. A. Ozerov

doi:10.1007/s11094-019-02047-3

Synthesis and Antiglycation Activity of Novel S-Carboxyalkyl Derivatives of 2-Thiouracil

Autores: Spasov A.¹^,2, Geisman A.¹^,2, Kosolapov V.¹, Babkov D.¹, Rashchenko A.¹, Babkova V.¹, Zakhar’yashcheva O.¹, Ozerov A.¹^,2
Afiliações:
1. Volgograd State Medical University
2. Volgograd Medical Science Center
Edição: Volume 53, Nº 7 (2019)
Páginas: 610-615
Seção: Article
URL: https://journals.rcsi.science/0091-150X/article/view/245897
DOI: https://doi.org/10.1007/s11094-019-02047-3
ID: 245897

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Resumo

S-carboxyalkyl derivatives of 2-thiouracil were synthesized and their pharmacological activity was studied. Several of the compounds were characterized by antiglycation activity. These compounds had no effect on PPAR or glucokinase activity and had weak activity in cleaving protein crosslinks.