Synthesis and Antiglycation Activity of Novel S-Carboxyalkyl Derivatives of 2-Thiouracil
- Authors: Spasov A.A.1,2, Geisman A.N.1,2, Kosolapov V.A.1, Babkov D.A.1, Rashchenko A.I.1, Babkova V.A.1, Zakhar’yashcheva O.Y.1, Ozerov A.A.1,2
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Affiliations:
- Volgograd State Medical University
- Volgograd Medical Science Center
- Issue: Vol 53, No 7 (2019)
- Pages: 610-615
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245897
- DOI: https://doi.org/10.1007/s11094-019-02047-3
- ID: 245897
Cite item
Abstract
S-carboxyalkyl derivatives of 2-thiouracil were synthesized and their pharmacological activity was studied. Several of the compounds were characterized by antiglycation activity. These compounds had no effect on PPAR or glucokinase activity and had weak activity in cleaving protein crosslinks.
About the authors
A. A. Spasov
Volgograd State Medical University; Volgograd Medical Science Center
Email: vad-ak@mail.ru
Russian Federation, Volgograd; Volgograd
A. N. Geisman
Volgograd State Medical University; Volgograd Medical Science Center
Email: vad-ak@mail.ru
Russian Federation, Volgograd; Volgograd
V. A. Kosolapov
Volgograd State Medical University
Author for correspondence.
Email: vad-ak@mail.ru
Russian Federation, Volgograd
D. A. Babkov
Volgograd State Medical University
Email: vad-ak@mail.ru
Russian Federation, Volgograd
A. I. Rashchenko
Volgograd State Medical University
Email: vad-ak@mail.ru
Russian Federation, Volgograd
V. A. Babkova
Volgograd State Medical University
Email: vad-ak@mail.ru
Russian Federation, Volgograd
O. Yu. Zakhar’yashcheva
Volgograd State Medical University
Email: vad-ak@mail.ru
Russian Federation, Volgograd
A. A. Ozerov
Volgograd State Medical University; Volgograd Medical Science Center
Email: vad-ak@mail.ru
Russian Federation, Volgograd; Volgograd