Synthesis and Antiglycation Activity of Novel S-Carboxyalkyl Derivatives of 2-Thiouracil

A. A. Spasov; A. N. Geisman; V. A. Kosolapov; D. A. Babkov; A. I. Rashchenko; V. A. Babkova; O. Yu. Zakhar’yashcheva; A. A. Ozerov

doi:10.1007/s11094-019-02047-3

Synthesis and Antiglycation Activity of Novel S-Carboxyalkyl Derivatives of 2-Thiouracil

作者: Spasov A.¹^,2, Geisman A.¹^,2, Kosolapov V.¹, Babkov D.¹, Rashchenko A.¹, Babkova V.¹, Zakhar’yashcheva O.¹, Ozerov A.¹^,2
隶属关系:
1. Volgograd State Medical University
2. Volgograd Medical Science Center
期: 卷 53, 编号 7 (2019)
页面: 610-615
栏目: Article
URL: https://journals.rcsi.science/0091-150X/article/view/245897
DOI: https://doi.org/10.1007/s11094-019-02047-3
ID: 245897

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S-carboxyalkyl derivatives of 2-thiouracil were synthesized and their pharmacological activity was studied. Several of the compounds were characterized by antiglycation activity. These compounds had no effect on PPAR or glucokinase activity and had weak activity in cleaving protein crosslinks.