Synthesis and Antiglycation Activity of Novel S-Carboxyalkyl Derivatives of 2-Thiouracil

A. A. Spasov; A. N. Geisman; V. A. Kosolapov; D. A. Babkov; A. I. Rashchenko; V. A. Babkova; O. Yu. Zakhar’yashcheva; A. A. Ozerov

doi:10.1007/s11094-019-02047-3

Synthesis and Antiglycation Activity of Novel S-Carboxyalkyl Derivatives of 2-Thiouracil

Авторы: Spasov A.¹^,2, Geisman A.¹^,2, Kosolapov V.¹, Babkov D.¹, Rashchenko A.¹, Babkova V.¹, Zakhar’yashcheva O.¹, Ozerov A.¹^,2
Учреждения:
1. Volgograd State Medical University
2. Volgograd Medical Science Center
Выпуск: Том 53, № 7 (2019)
Страницы: 610-615
Раздел: Article
URL: https://journals.rcsi.science/0091-150X/article/view/245897
DOI: https://doi.org/10.1007/s11094-019-02047-3
ID: 245897

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Аннотация

S-carboxyalkyl derivatives of 2-thiouracil were synthesized and their pharmacological activity was studied. Several of the compounds were characterized by antiglycation activity. These compounds had no effect on PPAR or glucokinase activity and had weak activity in cleaving protein crosslinks.