2-Thiomorpholino-5-Aryl-6H-1,3,4-Thiadiazine Hydrobromides and Their Ability to Inhibit Nonenzymatic Protein Glycosylation
- Авторлар: Sidorova L.1, Tseitler T.1, Emel’yanov V.1, Savateeva E.1, Maksimova N.1, Mochul’skaya N.1, Chereshnev V.2, Chupakhin O.1,3
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Мекемелер:
- First President of Russia B. N. Yeltsin Urals Federal University
- Institute of Immunology and Physiology, Urals Branch, Russian Academy of Sciences
- I. Ya. Postovskii Institute of Organic Synthesis, Urals Branch, Russian Academy of Sciences
- Шығарылым: Том 51, № 1 (2017)
- Беттер: 9-12
- Бөлім: Search for New Drugs
- URL: https://journals.rcsi.science/0091-150X/article/view/244494
- DOI: https://doi.org/10.1007/s11094-017-1547-x
- ID: 244494
Дәйексөз келтіру
Аннотация
Cyclocondensation of α-halogenacetophenones with an original 4-morpholine thiosemicarbazide was used to synthesize a group of new Captions: of the 1,3,4-thiadiazine group, containing a thiomorpholine fragment at position 2 of the thiadiazine ring. Two members of this group of compounds were found to produce effective inhibition of nonenzymatic protein glycosylation in an in vitro model system. These test results allow compounds containing phenyl and fluorophenyl fragments IIIa and IIIb to be recommended for further study in in vivo experiments.
Авторлар туралы
L. Sidorova
First President of Russia B. N. Yeltsin Urals Federal University
Хат алмасуға жауапты Автор.
Email: vlapp@isnet.ru
Ресей, 19 Mir Street, Ekaterinburg, 620002
T. Tseitler
First President of Russia B. N. Yeltsin Urals Federal University
Email: vlapp@isnet.ru
Ресей, 19 Mir Street, Ekaterinburg, 620002
V. Emel’yanov
First President of Russia B. N. Yeltsin Urals Federal University
Email: vlapp@isnet.ru
Ресей, 19 Mir Street, Ekaterinburg, 620002
E. Savateeva
First President of Russia B. N. Yeltsin Urals Federal University
Email: vlapp@isnet.ru
Ресей, 19 Mir Street, Ekaterinburg, 620002
N. Maksimova
First President of Russia B. N. Yeltsin Urals Federal University
Email: vlapp@isnet.ru
Ресей, 19 Mir Street, Ekaterinburg, 620002
N. Mochul’skaya
First President of Russia B. N. Yeltsin Urals Federal University
Email: vlapp@isnet.ru
Ресей, 19 Mir Street, Ekaterinburg, 620002
V. Chereshnev
Institute of Immunology and Physiology, Urals Branch, Russian Academy of Sciences
Email: vlapp@isnet.ru
Ресей, 106 Pervomaiskaya Street, Ekaterinburg, 620219
O. Chupakhin
First President of Russia B. N. Yeltsin Urals Federal University; I. Ya. Postovskii Institute of Organic Synthesis, Urals Branch, Russian Academy of Sciences
Email: vlapp@isnet.ru
Ресей, 19 Mir Street, Ekaterinburg, 620002; 22/20 Sofia Kovalevskaya Street, Ekaterinburg, 620137