2-Thiomorpholino-5-Aryl-6H-1,3,4-Thiadiazine Hydrobromides and Their Ability to Inhibit Nonenzymatic Protein Glycosylation
- 作者: Sidorova L.1, Tseitler T.1, Emel’yanov V.1, Savateeva E.1, Maksimova N.1, Mochul’skaya N.1, Chereshnev V.2, Chupakhin O.1,3
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隶属关系:
- First President of Russia B. N. Yeltsin Urals Federal University
- Institute of Immunology and Physiology, Urals Branch, Russian Academy of Sciences
- I. Ya. Postovskii Institute of Organic Synthesis, Urals Branch, Russian Academy of Sciences
- 期: 卷 51, 编号 1 (2017)
- 页面: 9-12
- 栏目: Search for New Drugs
- URL: https://journals.rcsi.science/0091-150X/article/view/244494
- DOI: https://doi.org/10.1007/s11094-017-1547-x
- ID: 244494
如何引用文章
详细
Cyclocondensation of α-halogenacetophenones with an original 4-morpholine thiosemicarbazide was used to synthesize a group of new Captions: of the 1,3,4-thiadiazine group, containing a thiomorpholine fragment at position 2 of the thiadiazine ring. Two members of this group of compounds were found to produce effective inhibition of nonenzymatic protein glycosylation in an in vitro model system. These test results allow compounds containing phenyl and fluorophenyl fragments IIIa and IIIb to be recommended for further study in in vivo experiments.
作者简介
L. Sidorova
First President of Russia B. N. Yeltsin Urals Federal University
编辑信件的主要联系方式.
Email: vlapp@isnet.ru
俄罗斯联邦, 19 Mir Street, Ekaterinburg, 620002
T. Tseitler
First President of Russia B. N. Yeltsin Urals Federal University
Email: vlapp@isnet.ru
俄罗斯联邦, 19 Mir Street, Ekaterinburg, 620002
V. Emel’yanov
First President of Russia B. N. Yeltsin Urals Federal University
Email: vlapp@isnet.ru
俄罗斯联邦, 19 Mir Street, Ekaterinburg, 620002
E. Savateeva
First President of Russia B. N. Yeltsin Urals Federal University
Email: vlapp@isnet.ru
俄罗斯联邦, 19 Mir Street, Ekaterinburg, 620002
N. Maksimova
First President of Russia B. N. Yeltsin Urals Federal University
Email: vlapp@isnet.ru
俄罗斯联邦, 19 Mir Street, Ekaterinburg, 620002
N. Mochul’skaya
First President of Russia B. N. Yeltsin Urals Federal University
Email: vlapp@isnet.ru
俄罗斯联邦, 19 Mir Street, Ekaterinburg, 620002
V. Chereshnev
Institute of Immunology and Physiology, Urals Branch, Russian Academy of Sciences
Email: vlapp@isnet.ru
俄罗斯联邦, 106 Pervomaiskaya Street, Ekaterinburg, 620219
O. Chupakhin
First President of Russia B. N. Yeltsin Urals Federal University; I. Ya. Postovskii Institute of Organic Synthesis, Urals Branch, Russian Academy of Sciences
Email: vlapp@isnet.ru
俄罗斯联邦, 19 Mir Street, Ekaterinburg, 620002; 22/20 Sofia Kovalevskaya Street, Ekaterinburg, 620137