2-Thiomorpholino-5-Aryl-6H-1,3,4-Thiadiazine Hydrobromides and Their Ability to Inhibit Nonenzymatic Protein Glycosylation
- Autores: Sidorova L.1, Tseitler T.1, Emel’yanov V.1, Savateeva E.1, Maksimova N.1, Mochul’skaya N.1, Chereshnev V.2, Chupakhin O.1,3
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Afiliações:
- First President of Russia B. N. Yeltsin Urals Federal University
- Institute of Immunology and Physiology, Urals Branch, Russian Academy of Sciences
- I. Ya. Postovskii Institute of Organic Synthesis, Urals Branch, Russian Academy of Sciences
- Edição: Volume 51, Nº 1 (2017)
- Páginas: 9-12
- Seção: Search for New Drugs
- URL: https://journals.rcsi.science/0091-150X/article/view/244494
- DOI: https://doi.org/10.1007/s11094-017-1547-x
- ID: 244494
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Resumo
Cyclocondensation of α-halogenacetophenones with an original 4-morpholine thiosemicarbazide was used to synthesize a group of new Captions: of the 1,3,4-thiadiazine group, containing a thiomorpholine fragment at position 2 of the thiadiazine ring. Two members of this group of compounds were found to produce effective inhibition of nonenzymatic protein glycosylation in an in vitro model system. These test results allow compounds containing phenyl and fluorophenyl fragments IIIa and IIIb to be recommended for further study in in vivo experiments.
Sobre autores
L. Sidorova
First President of Russia B. N. Yeltsin Urals Federal University
Autor responsável pela correspondência
Email: vlapp@isnet.ru
Rússia, 19 Mir Street, Ekaterinburg, 620002
T. Tseitler
First President of Russia B. N. Yeltsin Urals Federal University
Email: vlapp@isnet.ru
Rússia, 19 Mir Street, Ekaterinburg, 620002
V. Emel’yanov
First President of Russia B. N. Yeltsin Urals Federal University
Email: vlapp@isnet.ru
Rússia, 19 Mir Street, Ekaterinburg, 620002
E. Savateeva
First President of Russia B. N. Yeltsin Urals Federal University
Email: vlapp@isnet.ru
Rússia, 19 Mir Street, Ekaterinburg, 620002
N. Maksimova
First President of Russia B. N. Yeltsin Urals Federal University
Email: vlapp@isnet.ru
Rússia, 19 Mir Street, Ekaterinburg, 620002
N. Mochul’skaya
First President of Russia B. N. Yeltsin Urals Federal University
Email: vlapp@isnet.ru
Rússia, 19 Mir Street, Ekaterinburg, 620002
V. Chereshnev
Institute of Immunology and Physiology, Urals Branch, Russian Academy of Sciences
Email: vlapp@isnet.ru
Rússia, 106 Pervomaiskaya Street, Ekaterinburg, 620219
O. Chupakhin
First President of Russia B. N. Yeltsin Urals Federal University; I. Ya. Postovskii Institute of Organic Synthesis, Urals Branch, Russian Academy of Sciences
Email: vlapp@isnet.ru
Rússia, 19 Mir Street, Ekaterinburg, 620002; 22/20 Sofia Kovalevskaya Street, Ekaterinburg, 620137