2-Thiomorpholino-5-Aryl-6H-1,3,4-Thiadiazine Hydrobromides and Their Ability to Inhibit Nonenzymatic Protein Glycosylation
- Authors: Sidorova L.P.1, Tseitler T.A.1, Emel’yanov V.V.1, Savateeva E.A.1, Maksimova N.E.1, Mochul’skaya N.N.1, Chereshnev V.A.2, Chupakhin O.N.1,3
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Affiliations:
- First President of Russia B. N. Yeltsin Urals Federal University
- Institute of Immunology and Physiology, Urals Branch, Russian Academy of Sciences
- I. Ya. Postovskii Institute of Organic Synthesis, Urals Branch, Russian Academy of Sciences
- Issue: Vol 51, No 1 (2017)
- Pages: 9-12
- Section: Search for New Drugs
- URL: https://journals.rcsi.science/0091-150X/article/view/244494
- DOI: https://doi.org/10.1007/s11094-017-1547-x
- ID: 244494
Cite item
Abstract
Cyclocondensation of α-halogenacetophenones with an original 4-morpholine thiosemicarbazide was used to synthesize a group of new Captions: of the 1,3,4-thiadiazine group, containing a thiomorpholine fragment at position 2 of the thiadiazine ring. Two members of this group of compounds were found to produce effective inhibition of nonenzymatic protein glycosylation in an in vitro model system. These test results allow compounds containing phenyl and fluorophenyl fragments IIIa and IIIb to be recommended for further study in in vivo experiments.
About the authors
L. P. Sidorova
First President of Russia B. N. Yeltsin Urals Federal University
Author for correspondence.
Email: vlapp@isnet.ru
Russian Federation, 19 Mir Street, Ekaterinburg, 620002
T. A. Tseitler
First President of Russia B. N. Yeltsin Urals Federal University
Email: vlapp@isnet.ru
Russian Federation, 19 Mir Street, Ekaterinburg, 620002
V. V. Emel’yanov
First President of Russia B. N. Yeltsin Urals Federal University
Email: vlapp@isnet.ru
Russian Federation, 19 Mir Street, Ekaterinburg, 620002
E. A. Savateeva
First President of Russia B. N. Yeltsin Urals Federal University
Email: vlapp@isnet.ru
Russian Federation, 19 Mir Street, Ekaterinburg, 620002
N. E. Maksimova
First President of Russia B. N. Yeltsin Urals Federal University
Email: vlapp@isnet.ru
Russian Federation, 19 Mir Street, Ekaterinburg, 620002
N. N. Mochul’skaya
First President of Russia B. N. Yeltsin Urals Federal University
Email: vlapp@isnet.ru
Russian Federation, 19 Mir Street, Ekaterinburg, 620002
V. A. Chereshnev
Institute of Immunology and Physiology, Urals Branch, Russian Academy of Sciences
Email: vlapp@isnet.ru
Russian Federation, 106 Pervomaiskaya Street, Ekaterinburg, 620219
O. N. Chupakhin
First President of Russia B. N. Yeltsin Urals Federal University; I. Ya. Postovskii Institute of Organic Synthesis, Urals Branch, Russian Academy of Sciences
Email: vlapp@isnet.ru
Russian Federation, 19 Mir Street, Ekaterinburg, 620002; 22/20 Sofia Kovalevskaya Street, Ekaterinburg, 620137