Email this article Generation of Reactive Oxygen Species in Peripheral Blood Lymphocytes of Patients with Prostate Cancer
- Authors: Grekhova A.K.1, Gorbacheva L.B.1
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Affiliations:
- N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
- Issue: Vol 160, No 5 (2016)
- Pages: 709-711
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236909
- DOI: https://doi.org/10.1007/s10517-016-3256-y
- ID: 236909
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Abstract
The study revealed a two-fold elevation of ROS production in peripheral blood lymphocytes of the patients with prostate cancer (from 0.48±0.04 to 0.93±0.12 rel. units) together with significant variability of individual values. Hormone therapy had no effect on the mean and individual ROS levels. In contrast, organometallic cytostatics cisplatin and morfozol 2-fold increased ROS generation in lymphocytes of patients with prostate cancer above the enhanced level of this parameter determined by tumor growth.
About the authors
A. K. Grekhova
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Author for correspondence.
Email: annagrekhova1@gmail.com
Russian Federation, Moscow
L. B. Gorbacheva
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: annagrekhova1@gmail.com
Russian Federation, Moscow
