Vol 23, No 3 (2015)
- Year: 2015
- Articles: 24
- URL: https://journals.rcsi.science/pavlovj/issue/view/264
- DOI: https://doi.org/10.17816/PAVLOVJ233
AGE-RELATED AND STRESS-INDUCED PROTEINOPATHY OF CEREBRAL NEURONS IN RATS
Abstract
A study of morphological and functional changes in neurons and glial cells of the cerebral cortex of white rats at the stages of aging and stress-induced neurodegeneration under experiment was investigated. It was found that the age-related neurodegenerative changes in somatosensory cortex neurons of white rats at the age of 30 months are characterized with pronounced signs of proteoinopathy and developing of apoptosis, which is enhanced by exposure to stress factors in clear violation of protein metabolism in the form of accumulation of intra- and extracellular amyloid.
I.P. Pavlov Russian Medical Biological Herald. 2015;23(3):7-10
7-10
ADENOCARCINOMA OF MINOR DUODENAL PAPILLA
Abstract
The article presents a rare clinical case of adenocarcinoma of the minor duodenal papilla at man - 51 years old. This was the first case in our practice since 2002 among the 310 pancreaticoduodenal complexes with varied pathologies studied. Histologically, the tumor is similar to pancreatic ductal adenocarcinoma and ampullar carcinoma (pancreatobiliary type). To avoid diagnostic errors of gross examination, it is highly important to follow the step-by-step algorithm of dissection.
I.P. Pavlov Russian Medical Biological Herald. 2015;23(3):11-17
11-17
IMMUNOHISTOCHEMICAL ANALYSIS OF LIVER TISSUE IN SPONTANEOUS REGENERATION IN THE RECOVERY PERIOD AFTER EXPERIMENTAL FIBROSIS
Abstract
We investigated the process of spontaneous liver regeneration after chemically induced experimental fibrosis. The obtained data about activity of some liver metalloproteinases, shown important role of each metalloproteinases at different stages of liver recovery.
I.P. Pavlov Russian Medical Biological Herald. 2015;23(3):18-26
18-26
FEATURES OF PANCREATICODUODENAL REGION BLOOD SUPPLY IN THE SURGICAL TREATMENT OF CHRONIC PANCREATITIS
Abstract
The study showed that the head of the pancreas and duodenum receive arterial blood from the anterior and posterior of the pancreatic-duodenal arcs. Posterior arc gives to the intestine more branches than the anterior one. Its impotent during an operations when elements of the anterior arc were ligated. Also found that the inferior pancreatic artery, dorsal pancreatic artery, arteries are interchangeable. Both arteries in one complex were not found.
I.P. Pavlov Russian Medical Biological Herald. 2015;23(3):27-31
27-31
PSYCHOPHYSIOLOGICAL AND CARDIOVASCULAR MECHANISMS SUPPORTING THE LEARNING PROCESSIS OF THE STUDENTS
Abstract
Research of the psychological and physiological status of the medical students before and after solving the multiple choice computer questions were explored. Individual psychological and physiological parameters were studied in students with best results and students with worse results of the solving of the tasks. It was shown, that the less resulted students solving of the multiple choice questions attained by chainging more numbers of the physiological parameters and attended of psychoemotional tension. Obviously it was connected with low level of the students knowledge and was accompanied by increasing of general tension. More resultative students had better psycho-physiological parameters before solving tests.
I.P. Pavlov Russian Medical Biological Herald. 2015;23(3):32-36
32-36
METABOLIC ASPECTS OF PHARMACOLOGICAL DEPRIVATION PERIPHERAL NICOTINIC SENSITIVE CHOLINERGIC SYNAPSES
Abstract
Content of ATP, ADP, of AMP and activity of isozyme systems LDH in the cranial cervical sympathetic ganglia (CSSG) rabbits was investigated with partial and complete deprivation of N-cholinergic (N-HE) synapses. Dynamics of activity of LDH and content of macroergs in deprivation N-HE synapses indicates that blockade of N-HE synapses results in sympathetic ganglia to significant energy shortages and disruption of energy homeostasis. It is assumed that changes in energy metabolism are the main cause CSSG hypofunction observed during pharmacological blockade by antagonists N-HE synapses.
I.P. Pavlov Russian Medical Biological Herald. 2015;23(3):37-41
37-41
SOME INDICATORS OF QUALITY OF LIFE OF PATIENTS WITH HIV INFECTION IN CONDITIONS OF THE REPUBLIC OF TAJIKISTAN
Abstract
This article presents an analysis of some indicators of the quality of life (QOL) in 100 HIV-infected patients living in the Republic of Tajikistan. The evaluation was conducted using the SF-36 questionnaire. The age of respondents ranged from 17 to 56 years, of which 61,7% were men and 38,3% - women. Comparative analysis QOL revealed in HIV-infected women's higher rates of psychosocial component scale SF-36 than men living with HIV. Despite this availability of the problem is a significant factor that reduces the level of QOL of people living with HIV (PLHIV). In patients from the study group the decrease QOL was due to statistically low levels (p<0,05) on the scale of the psychosocial aspects - social (51,4 points - in the study group, 76,1 points - in the control), and role functioning due to emotional condition (56,9 and 77,2 points, respectively), general health (49,3 and 63,4 points), mental health (51,2 and 70,1 points), as well as the vital activity (49,6 and 63,4 points). QOL of PLHIV indicators are set, such as general health, family, emotional sphere, social contacts, vital activity, level of education, level of stigma and discrimination, as well as access to health services.
I.P. Pavlov Russian Medical Biological Herald. 2015;23(3):42-48
42-48
METHODS OF IDENTIFICATION OF DRUGS AS P-GLYCOPROTEIN SUBSTRATES
Abstract
The article presents an original method for determining belonging of drugs to the substrates of the transport protein P-glycoprotein (Pgp). This methodics is based on a comparison of the pharmacokinetic parameters of the test substrate before and after a course of administration of the inductor (rifampicin) and inhibitor (verapamil) of the transport protein. If the content of test substance in organism is reduced after Pgp inductor administration, and increased after the inhibitor administration, we conclude that this substance is Pgp substrate. For approbation of developed technique we examined by blind method the pharmacokinetics of fexofenadine - known Pgp substrate at a dose of 67,5 mg/kg, before and after the 14-days administration of rifampicin (40 mg/kg twice daily) and verapamil (a daily dose of 20 mg/kg three times a day). It was revealed that after a course administration of verapamil maximum concentration of fexofenadine, its area under the concentration-time curve and half-life were significantly increased, as well as the time of maximum concentration was decreased. In contrast, rifampicin course administration resulted in a decrease in the area under the curve concentration-time and an increase in total clearance of marker substrate of Pgp, wich proves the adequacy of methods.
I.P. Pavlov Russian Medical Biological Herald. 2015;23(3):49-53
49-53
EFFECT OF AN INHIBITOR OF DPP-4-VTLDAGLIPTIN FOR THE FUNCTIONAL ACTIVITY OF P-GLYCOPROTEIN IN VIVO
Abstract
In the in vivo study in rabbits the effect of vildagliptin at 5 mg / kg body weight of the functional activity of the protein transporter P-glycoprotein (P-gp, ABCB1 protein) was studied. P-gp activity was evaluated by its pharmacokinetics marker substrate - fexofenadine after a single intragastric administration. Applying vildagliptin for 14 days led to an increase in the maximum concentration of fexofenadine, its half-life, area under the concentration-time curve from zero to the last point of drawing blood, area under the concentration-time curve from zero to infinity, and the retention time of marker substrate and reduce the overall clearance rate of absorption and distribution volume, indicating that the inhibition of the functional activity of the protein transporter at the level of the whole organism.
I.P. Pavlov Russian Medical Biological Herald. 2015;23(3):54-60
54-60
CHANGE OF THE FUNCTIONAL STATE OF THE ORGANISM OF MEDICAL PERSONNEL OF THE PERINATAL CENTER IN THE DYNAMICS OF THE WORK SHIFT
Abstract
The profound study of working conditions of doctors and average medical personnel made possible to conduct their hygienic estimation and find the degree of the influence of production process on the functional state of the organism of the workers in the dynamics of work shift and on the age aspect.
I.P. Pavlov Russian Medical Biological Herald. 2015;23(3):61-65
61-65
IMPACT MEDICAL-SOCIAL FACTORS AND BEHAVIOR OF PATIENT WITH ECTOPIC PREGNANCY ON THE DURATION OF HOSPITAL STAY
Abstract
The study deals to the problems of planning of hospital care in ectopic pregnancy. It is shown that the importance of the factors based on medical and social characteristics of the patient, determined by the ability of management influence, by forming a comprehensive prevention programs with the goal of reducing the probability of prolonged hospital stay. The use of this approach at the level of the municipality substantially increases the economic and social efficiency.
I.P. Pavlov Russian Medical Biological Herald. 2015;23(3):66-70
66-70
THE SYSTEM OF PROPHYLAXIS OF NONINFECTIOUS DISEASES AT BUDGETARY SPHERE WORKERS
Abstract
In the article the characteristic of a structure of arrangements about the formation of healthy lifestyle and prophylaxis of noninfectious diseases is given. The main content of complex purpose programs about prophylaxis of noninfectious diseases at a level of Russian Federation subjects is opened. The algorithm of forming healthy lifestyle is performed, and functional reserving of basic elements of medical prophylaxis as well.
I.P. Pavlov Russian Medical Biological Herald. 2015;23(3):71-75
71-75
METHODOLOGICAL AND ORGANIZATIONAL BASES OF DEVELOPMENT OF PUBLIC HEALTH AS A PRIORITY SUBSYSTEM OF SOCIAL AND ECONOMIC SPHERE OF REGION
Abstract
Methodological and methodical bases of creation of medico-social of insurance cluster are considered by in the article. The integration action of sectors of the economy and social sphere to improve the health of workers of the economically active working age (workers of metallurgical and mining enterprises) is substantiated. The region is considered as an organized and structured socio-economic system. The development of this system is based on the optimal linkages between priority sectors.
I.P. Pavlov Russian Medical Biological Herald. 2015;23(3):76-82
76-82
RESULTS OF 5-YEAR OBSERVATION FOR PATIENTS WITH HEART DISEASE
Abstract
The article presents the five-year dynamics of patients with rheumatic heart disease, changes in echocardiographic indicators, quality of life and the course of chronic heart failure. It was found that the negative dynamics of the echocardiography indicators does not lead to progression of heart failure and a significant deterioration in the quality of life of patients. Cases of a combination of type II diabetes, atrial fibrillation, severe mitral stenosis, left atrial dilation lead to an increased risk of death in patients with rheumatic heart disease.
I.P. Pavlov Russian Medical Biological Herald. 2015;23(3):83-87
83-87
CORRELATION OF NEUROPHYSIOLOGICAL CHARACTERISTICS OF PATIENTS WITH LUMBAR VERTEBRAL CHRONIC PAIN SYNDROME
Abstract
Analyzed the performance of MRI studies of patients with radicular and reflex syndromes against chronic vertebrogenic pain syndrome: structural patanatomic changes do not explain the differences in clinical manifestations in groups. Correlation analysis of physiological parameters of patients in both groups marked desynchronization neuronal excitability of the spinal centers, the violation of the parish of excitation thereto, the phenomenon of Central sensitization, these functional features are more pronounced in patients with reflex syndromes.
I.P. Pavlov Russian Medical Biological Herald. 2015;23(3):88-93
88-93
COMPARATIVE ANALYSIS OF ENDOSCOPIC TREATMENT OF INGUINAL HERNIAS
Abstract
The objective of the research is a comparison of laparoscopic and endoscopic methods of treatment of inguinal hernias. In the period from 2011 to 2012, 44 unilateral inguinal hernia repairs were performed till the IIIa stage according to the classification by L. Nayhus. 24 of these operations underwent a laparoscopic hernia repair method by (TAPP) - the first group, and 20 of them underwent an endoscopic method of hernia repair by (TEP) - the second group. All hernia repairs were performed by standards, using the same tools and mesh prosthesis (polypropylene mesh 15 x 15 cm). The duration of the operation was higher in the second group. The length of hospitalization did not differ. Pain syndrome was higher in the first group. Published experience in this study shows the advantage of the (TEP) method in the postoperative period for patients, which operated in relation to inguinal hernia till the IIIa stage.
I.P. Pavlov Russian Medical Biological Herald. 2015;23(3):94-98
94-98
EPITHELIAL AND STROMAL COMPONENTS IN DUCTAL BREAST CANCER
Abstract
Currently, most of the scientific work is focused on the study of epithelial-stromal relations play an important role in the progression of epithelial tumors towards dedifferentiated phenotype. The aim of our research - the study of morphological properties of anaplastic tumor sites and surrounding stroma of ductal breast cancer. Epithelial-stromal interactions in ductal breast cancer cause its aggressive biological behavior, resistance to chemotherapy and varying depending on the survival of tumor differentiation. Heterogeneity is manifested in the ductal carcinoma anaplastic appearance (sarcomatoid) component, which traced the ability of epithelial tumor cells acquire the properties of mesenchymal cells do not require the stroma and have an aggressive malignant potential impact on survival of patients.
I.P. Pavlov Russian Medical Biological Herald. 2015;23(3):99-105
99-105
INFLUENCE OF RHINOSURGERY ON THE COURSE OF OBSTRUCTIVE APNEA SYNDROME
Abstract
Purpose of this open study was the evaluation of rhinosurgery effect on the course of obstructive apnea syndrome (OSA). 25 patients 25-60 years old with nasal obstruction and OSA were examined: neurologic, otorhynolaryngologic studies and cardiopulmonary monitoring were conducted before and 3-4 months after nasal surgery. 50% or more decline of sleep apnea index (SAI) was observed in 6 (24%) persons, in other 6 (24%) persons SAI has grown up 50% or more, no significant difference was shown in 13 patients (52%). No correlation of SAI shift after surgical treatment with physical, anamnestic and respiratory data were demonstrated. Nasal surgery leads to positive results referring to pharyngeal obstruction not more than in 24% of cases. Today we have no proved predictors of high nasal correction effect on the severity of OSA.
I.P. Pavlov Russian Medical Biological Herald. 2015;23(3):106-110
106-110
REGIONAL FEATURES OF DERMATOGLYPHICS IN PHYSICAL HEALTH MEN WITH CARIES OF LOW INTENSITY LEVEL
Abstract
Discovered some, mostly solitary, differences in administrative-territorial distribution of dermatoglyphic signs for somatically healthy men first mature age with low intensity of caries that it is not possible to distinguish dermatoglyphic complexes typical, for a given level of intensity of caries, for a specific region of Ukraine. Dermatoglyphics differences at low intensity of caries in the direction of the west↔south are regarded by us as a manifestation of populational-regional characteristics of the gene pool of Ukrainians male that fulfill the criteria of complete physical health
I.P. Pavlov Russian Medical Biological Herald. 2015;23(3):111-115
111-115
AMINO-ACID COMPOSITION OF UROLOGICAL HERBAL TEA
Abstract
Qualitative & quantitative amino-acid composition of urological herbal tea “Uvaur” which includes manzanita leaves, tickseed, birch gemmae. 19 amino acids are determined in the herbal tea, 9 of which are indispensable. The total content of amino acids is 6,998%, in which 12,34% glutamic acid, 10,38% aspartic acids, 8,69% leucine.
I.P. Pavlov Russian Medical Biological Herald. 2015;23(3):116-119
116-119
AN ANALYSIS OF PROBABLE MECHANISMS OF ANTIDEPRESSANT ACTIVITY OF NEURONAL N-METHYL-D-ASPARTATE RECEPTOR BLOCKERS
Abstract
Slow appearance of therapeutic action and partial therapeutic efficiency of used today antidepressants demand otherwise approaches for creation on principle new antidepressants. One from prototypes such drugs is ketamine possessing by capacity fast to suppress the symptoms of refractory depression. However a nature of antidepressant activity did not ascertained decisively. The most popular hypotheses of antidepressant action of ketamine and other N-methyl-D-aspartate receptors blockers were analyzed in this review.
I.P. Pavlov Russian Medical Biological Herald. 2015;23(3):120-125
120-125
QUALITY OF LIFE ASSESSMENT USING A QUESTIONNAIRES IN PATIENTS WITH VENOUS DISEASE OF LOWER EXTREMITIES
Abstract
The article presents the modern concept of the term "quality of life" and the methodology of his research with the help of general and specific questionnaires for patients with venous disease, including venous thrombosis. Analysis of the quality of life is essential to evaluate the effectiveness of treatment and in conjunction with objective data makes it possible to obtain comprehensive information about the influence of a drug or surgical treatment for the patient in a remote period.
I.P. Pavlov Russian Medical Biological Herald. 2015;23(3):126-133
126-133
THE ANALYSIS OF CONTEMPORARY METHODS OF OCCLUSION ESTIMATION AND REGISTRATION ON THE STAGE OF ORTHOPEDIC DENTISTRY TREATMENT
Abstract
A survey of literature on the subject of occlusion diagnostic methods on the stage of orthopedic dentistry treatment is represented. Different contemporary methods of occlusion registration and analysis are described. The essential advantages and drawbacks of every referred method are specified.
I.P. Pavlov Russian Medical Biological Herald. 2015;23(3):134-139
134-139
THE PECULIARITIES OF DENTAL PATHOLOGY IN PEOPLE OF ELDER AGE GROUPS
Abstract
The peculiarities of the course of mouth cavity diseases among elderly and old-aged people with account of gender differences are observed in the article. It is shown that the loss of tooth with the following functional changes heads the list of dental changes in elderly and old-aged patients. The estimation of this group of people’s requirement of orthopedic dental help is provided in the article.
I.P. Pavlov Russian Medical Biological Herald. 2015;23(3):140-147
140-147