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Post a Comment Problems in differential diagnosis of secondary hyperparathyroidism
- Authors: Shulkina S.G.1, Sirin D.O.1, Smirnova E.N.1, Zhelobov V.G.1, Kolomeets N.Y.1, Loran E.A.1, Perevoschikov A.N.1, Koryagin V.S.1
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Affiliations:
- E.A. Vagner Perm State Medical University
- Issue: Vol 38, No 1 (2021)
- Pages: 161-167
- Section: Clinical case
- URL: https://journals.rcsi.science/PMJ/article/view/65256
- DOI: https://doi.org/10.17816/pmj381161-167
- ID: 65256
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Abstract
Hyperparathyroidism is an endocrine disease characterized by excessive production of parathyroid hormone in the main cells of the parathyroid glands. Depending on the cause of this disease, there are primary, secondary (SHPT) and tertiary hyperparathyroidism. The most common causes of SHPT are vitamin D deficiency and chronic kidney disease (CKD). Vitamin D is converted to its active form by hydroxylation in the renal tubules. Developmental abnormalities and chronic kidney diseases lead to atrophy of the tubular epithelial cells that causes a violation of vitamin D metabolism and the development of SHPT, which in turn are accompanied by a violation of calcium-phosphorus metabolism and a syndrome of musculoskeletal disorders. This article presents an analysis of a clinical case of a patient diagnosed secondary hyperparathyroidism against the background of vitamin D deficiency combined with polycystic kidney disease. This clinical case reflects the complexity of the differential diagnosis of the disease and the tactics of patient's management.
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##article.viewOnOriginalSite##About the authors
S. G. Shulkina
E.A. Vagner Perm State Medical University
Author for correspondence.
Email: shulkina-s@mail.ru
MD, PhD, Associate Professor, Department of Polyclinic Therapy
Russian Federation, PermD. O. Sirin
E.A. Vagner Perm State Medical University
Email: shulkina-s@mail.ru
student
Russian Federation, PermE. N. Smirnova
E.A. Vagner Perm State Medical University
Email: shulkina-s@mail.ru
MD, PhD, Professor, Head of Department of Endocrinology and Clinical Pharmacology
Russian Federation, PermV. G. Zhelobov
E.A. Vagner Perm State Medical University
Email: shulkina-s@mail.ru
MD, PhD, Professor, Head of Department of Polyclinic Therapy
Russian Federation, PermN. Yu. Kolomeets
E.A. Vagner Perm State Medical University
Email: shulkina-s@mail.ru
Candidate of Medical Sciences, Associate Professor, Department of Propedeutics of Children’s Diseases
Russian Federation, PermE. A. Loran
E.A. Vagner Perm State Medical University
Email: shulkina-s@mail.ru
Candidate of Medical Sciences, Assistant, Department of Endocrinology and Clinical Pharmacology
Russian Federation, PermA. N. Perevoschikov
E.A. Vagner Perm State Medical University
Email: shulkina-s@mail.ru
student
Russian Federation, PermV. S. Koryagin
E.A. Vagner Perm State Medical University
Email: shulkina-s@mail.ru
student
Russian Federation, PermReferences
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