Email this article 
Post a Comment Experimental study of neuropsychotropic activity
- Authors: Krasnova A.I.1, Pulina N.A.1, Polezhaeva V.D.1
-
Affiliations:
- Perm State Pharmaceutical Academy
- Issue: Vol 40, No 3 (2023)
- Pages: 139-145
- Section: Biology and experimental medicine
- URL: https://journals.rcsi.science/PMJ/article/view/254873
- DOI: https://doi.org/10.17816/pmj403139-145
- ID: 254873
Cite item
Full Text
Abstract
Objective. To study the neuropsychotropic activity of 2,4-dioxobutanoic acid derivatives containing a fragment of benzimidazole as well as to determine the relationship between the structure of substances and their biological effects.
Materials and methods. The spectrum of neuropsychotropic activity of 2,4-dioxobutanoic acid derivatives with benzimidazole was studied on experimental animals using the «open field», «black-and-white camera», and «extrapolation deliverance» tests.
Results. A compound with potential anxiolytic properties has been identified. The dependence of the manifestation of anxiogenic or anxiolytic properties in the presence of mono- or bicyclic arenes in the structure, respectively, is shown.
Conclusions. 2,4-Dioxobutane acids containing a fragment of benzimidazole are of interest for the search for substances with neuropsychotropic activity. The results of the “structure-activity” analysis should be used in further targeted synthesis.
Full Text
##article.viewOnOriginalSite##About the authors
Anastasiya I. Krasnova
Perm State Pharmaceutical Academy
Author for correspondence.
Email: krasnova_ai@mail.ru
ORCID iD: 0000-0002-5363-8783
SPIN-code: 3520-1728
Scopus Author ID: 56430747900
Candidate of Pharmaceutical Sciences, Associate Professor, Department of Pharmacology
Russian Federation, PermNataliya A. Pulina
Perm State Pharmaceutical Academy
Email: pulina-nata@mail.ru
ORCID iD: 0000-0002-0435-0484
SPIN-code: 3972-0441
Scopus Author ID: 7801572754
Doctor of Pharmaceutical Sciences, Professor, Head of the Department of Pharmaceutical Technology
Russian Federation, PermValeriya D. Polezhaeva
Perm State Pharmaceutical Academy
Email: polezgaevalera@inbox.ru
postgraduate student, Assistant of the Department of Pharmaceutical Technology
Russian Federation, PermReferences
- Brishty S.R., Hossain M.J., Khandaker M.U., Faruque M.R.I., Osman H., Rahman S.M.A. A Comprehensive Account on Recent Progress in Pharmacological Activities of Benzimidazole Derivatives. Front Pharmacol 2021; 12: 762–807.
- Duarte C.D., Barreiro E.J., Fraga C.A. Privileged structures: a useful concept for the rational design of new lead drug candidates. Mini Rev Med Chem. 2007; 7 (11): 1108–19.
- Hauser A.S., Attwood M.M., Rask-Andersen M., Schiöth H.B., Gloriam D.E. Trends in GPCR drug discovery: new agents, targets and indications. Nat Rev Drug Discov. 2017; 16 (12): 829–842.
- Encyclopedia of medicines 2020 of the Russian register of medicines. Moscow: VEDANTA 2019: 1536 (in Russian).
- Pulina N.A., Sobin F.V., Yushkova T.A., Krasnova A.I., Yushkov V.V. 2-Hydroxy-4-methylphenyl-4-oxo-2-butenoate of thiazonyl ammonium, possessing hypoglycemic and nootropic activity: Patent RF № 2512291 from 26.07.2011: available at: http://www.findpatent.ru/patent/251/2512291.html (in Russian).
- Pulina N.A., Sobin F.V., Syropyatov B.Ya., Mokin P.A., Kovaleva M. Yu. Synthesis and anticoagulant activity of α-oxocarbonic acid derivatives. Pharm. Chem. J. 2012; 46 (12): 15–18 (in Russian).
- State Pharmacopoeia of the Russian Federation of the Ministry of Health of the Russian Federation 14th ed. Мoscow 2018: 1: 1814 (in Russian).
- Guidelines for conducting preclinical studies of drugs. Part One. Pod red. A.N. Mironova. Мoscow: Grif i K. 2013; 944 (in Russian).
Supplementary files
