Relevance. According to modern recommendations, migraine treatment should last at least 12 months. In this regard, adherence to patient therapy is the main condition for its success. Nevertheless, among patients receiving p-adrenoblockers, anticonvulsants, antidepressants, 40% of patients refuse therapy within 1 month, 24-25% remain on treatment after 6 months, 13-16% take drugs for up to 12 months. The main reason for refusing therapy, especially in the first weeks, is the poor tolerance of these drugs (psychotropic effects, sedation, bradycardia). The aim of the study lies in examining the efficacy and safety of the appointment of candesartan (Ordiss) to patients with chronic migraine (according to the criteria of the International Classification of Headache III, 2013) and arterial hypertension (increase in systolic blood pressure - BP of above 140, diastolic - 90 mm Hg). Materials and methods. Treatment was conducted in 72 patients with chronic migraine and hypertension (9 men, 63 women, mean age 46.4±9.7 years). Evaluation of the effectiveness was carried out by analyzing the data of the diary of a headache (indicators of the number of days with a headache, days with migraine). At each of the visits BP was recorded. Evaluation was carried out before the start of treatment, after 1,3 and 6 months. Results. There was a statistically significant decrease in days with headache: from 22.3±6.0 days to 10.4±3.5 days after 1 month, 8.8±3.1 days after 3 months and 6.2±2.7 day after 6 months of therapy (everywhere p<0.01). A statistically significant decrease was also observed in the dynamics of the indicator of days with migraine: from 16.9±5.4 days before treatment to 7.3±2.9 days after 1 month, 6.5±2.7 days -after 3 months, 4.9±1.8 days - after 6 months. Treatment with candesartan (Ordiss) also led to the normalization of BP in 92.8% of patients. 2 patients interrupted treatment due to the development of general weakness and increased fatigue. 5 (6.9%) patients also had general weakness and increased fatigue, but these phenomena were transient. Conclusions. Candesartan (Ordiss) can be recommended for the treatment of patients with chronic migraine and hypertension.