NSAID-associated lesions of the gastrointestinal tract and their complications: ways of preventing


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Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used in clinical practice by a large number of specialists: from traditional rheumatological and neurological practices to gynecological doctors and many other specialists. This fact is explained by the pharmacological properties of NSAIDs, being an effective tool in the therapy of pain and inflammation. At the same time, taking into account the mechanism of action of these drugs, it is necessary to take into account class-specific side effects of NSAIDs, primarily on the part of the gastrointestinal tract. Particular attention should be paid to patients who need long-term use and have risk factors for the development of NSAID-induced gastro-toxic lesions. Therefore, an important task in the appointment of any NSAID is the right choice in favor of an effective and safest drug with a selective mechanism of action. The use of selective inhibitors of cyclooxygenase-2 allows to minimize the incidence of the development of NSAID-induced complications, including bleeding. A popular and widely used in the clinical practice drug from this group of drugs is nimesulide, which has advantages over traditional NSAIDs, is effective and practically safe in the management of acute and chronic pain.

About the authors

I. G. Pakhomova

I.I.Mechnikov State Northwestern Medical University of the Ministry of Health of the Russian Federation

Email: pakhomova-inna@yandex.ru
канд. мед. наук, доц. каф. пропедевтики внутренних болезней, гастроэнтерологии и диетологии 191015, Russian Federation, Saint Petersburg, ul. Kirochnaia, d. 41

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