Study of dCTCF Insulator Activity in Drosophilamelanogaster Model Systems
- Авторы: Postika N.E.1, Ivlieva T.A.1, Georgiev P.G.1, Kyrchanova O.V.1
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Учреждения:
- Institute of Gene Biology, Russian Academy of Sciences
- Выпуск: Том 486, № 1 (2019)
- Страницы: 187-191
- Раздел: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/213004
- DOI: https://doi.org/10.1134/S1607672919030074
- ID: 213004
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Аннотация
Using transgenic Drosophila model systems, we showed that four binding sites for the architectural protein dCTCF per se cannot form an effective insulator that blocks enhancers and protects against the Polycomb-dependent repression. These results suggest that, in the known Drosophila insulators, the dCTCF protein functions in cooperation with other architectural proteins.
Об авторах
N. Postika
Institute of Gene Biology, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: nk.postika@gmail.com
Россия, Moscow, 119334
T. Ivlieva
Institute of Gene Biology, Russian Academy of Sciences
Email: nk.postika@gmail.com
Россия, Moscow, 119334
P. Georgiev
Institute of Gene Biology, Russian Academy of Sciences
Email: nk.postika@gmail.com
Россия, Moscow, 119334
O. Kyrchanova
Institute of Gene Biology, Russian Academy of Sciences
Email: nk.postika@gmail.com
Россия, Moscow, 119334
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