Study of dCTCF Insulator Activity in  Drosophila  melanogaster  Model Systems

N. E. Postika; T. A. Ivlieva; P. G. Georgiev; O. V. Kyrchanova

doi:10.1134/S1607672919030074

Study of dCTCF Insulator Activity in Drosophilamelanogaster Model Systems

Authors: Postika N.E.¹, Ivlieva T.A.¹, Georgiev P.G.¹, Kyrchanova O.V.¹
Affiliations:
1. Institute of Gene Biology, Russian Academy of Sciences
Issue: Vol 486, No 1 (2019)
Pages: 187-191
Section: Biochemistry, Biophysics, and Molecular Biology
URL: https://journals.rcsi.science/1607-6729/article/view/213004
DOI: https://doi.org/10.1134/S1607672919030074
ID: 213004

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Abstract

Using transgenic Drosophila model systems, we showed that four binding sites for the architectural protein dCTCF per se cannot form an effective insulator that blocks enhancers and protects against the Polycomb-dependent repression. These results suggest that, in the known Drosophila insulators, the dCTCF protein functions in cooperation with other architectural proteins.