Study of dCTCF Insulator Activity in  Drosophila  melanogaster  Model Systems

N. E. Postika; T. A. Ivlieva; P. G. Georgiev; O. V. Kyrchanova

doi:10.1134/S1607672919030074

Study of dCTCF Insulator Activity in Drosophilamelanogaster Model Systems

作者: Postika N.E.¹, Ivlieva T.A.¹, Georgiev P.G.¹, Kyrchanova O.V.¹
隶属关系:
1. Institute of Gene Biology, Russian Academy of Sciences
期: 卷 486, 编号 1 (2019)
页面: 187-191
栏目: Biochemistry, Biophysics, and Molecular Biology
URL: https://journals.rcsi.science/1607-6729/article/view/213004
DOI: https://doi.org/10.1134/S1607672919030074
ID: 213004

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详细

Using transgenic Drosophila model systems, we showed that four binding sites for the architectural protein dCTCF per se cannot form an effective insulator that blocks enhancers and protects against the Polycomb-dependent repression. These results suggest that, in the known Drosophila insulators, the dCTCF protein functions in cooperation with other architectural proteins.