Study of dCTCF Insulator Activity in Drosophilamelanogaster Model Systems
- Авторлар: Postika N.E.1, Ivlieva T.A.1, Georgiev P.G.1, Kyrchanova O.V.1
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Мекемелер:
- Institute of Gene Biology, Russian Academy of Sciences
- Шығарылым: Том 486, № 1 (2019)
- Беттер: 187-191
- Бөлім: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/213004
- DOI: https://doi.org/10.1134/S1607672919030074
- ID: 213004
Дәйексөз келтіру
Аннотация
Using transgenic Drosophila model systems, we showed that four binding sites for the architectural protein dCTCF per se cannot form an effective insulator that blocks enhancers and protects against the Polycomb-dependent repression. These results suggest that, in the known Drosophila insulators, the dCTCF protein functions in cooperation with other architectural proteins.
Авторлар туралы
N. Postika
Institute of Gene Biology, Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: nk.postika@gmail.com
Ресей, Moscow, 119334
T. Ivlieva
Institute of Gene Biology, Russian Academy of Sciences
Email: nk.postika@gmail.com
Ресей, Moscow, 119334
P. Georgiev
Institute of Gene Biology, Russian Academy of Sciences
Email: nk.postika@gmail.com
Ресей, Moscow, 119334
O. Kyrchanova
Institute of Gene Biology, Russian Academy of Sciences
Email: nk.postika@gmail.com
Ресей, Moscow, 119334
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