Enviar artigo por via de e-mail Study of dCTCF Insulator Activity in Drosophilamelanogaster Model Systems
- Autores: Postika N.E.1, Ivlieva T.A.1, Georgiev P.G.1, Kyrchanova O.V.1
-
Afiliações:
- Institute of Gene Biology, Russian Academy of Sciences
- Edição: Volume 486, Nº 1 (2019)
- Páginas: 187-191
- Seção: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journals.rcsi.science/1607-6729/article/view/213004
- DOI: https://doi.org/10.1134/S1607672919030074
- ID: 213004
Citar
Acesso aberto
Acesso está concedido
Somente assinantes
Resumo
Using transgenic Drosophila model systems, we showed that four binding sites for the architectural protein dCTCF per se cannot form an effective insulator that blocks enhancers and protects against the Polycomb-dependent repression. These results suggest that, in the known Drosophila insulators, the dCTCF protein functions in cooperation with other architectural proteins.
Sobre autores
N. Postika
Institute of Gene Biology, Russian Academy of Sciences
Autor responsável pela correspondência
Email: nk.postika@gmail.com
Rússia, Moscow, 119334
T. Ivlieva
Institute of Gene Biology, Russian Academy of Sciences
Email: nk.postika@gmail.com
Rússia, Moscow, 119334
P. Georgiev
Institute of Gene Biology, Russian Academy of Sciences
Email: nk.postika@gmail.com
Rússia, Moscow, 119334
O. Kyrchanova
Institute of Gene Biology, Russian Academy of Sciences
Email: nk.postika@gmail.com
Rússia, Moscow, 119334
Arquivos suplementares
