Synthesis of 3,5-Di-tert-butyl-1,2-dihydroxybenzene Derivatives and Their Effect on Free-Radical Oxidation of Hexane and Oxygen Activation Ability of Neutrophils
- 作者: Ksendzova G.1, Ostrovskaya N.1, Semenkova G.2, Sorokin V.2, Shishkanova P.2, Shadyro O.1,2
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隶属关系:
- Research Institute of Physical and Chemical Problems
- Belarusian State University
- 期: 卷 89, 编号 3 (2019)
- 页面: 391-398
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222778
- DOI: https://doi.org/10.1134/S1070363219030046
- ID: 222778
如何引用文章
详细
C6-Substituted derivatives of 3,5-di-tert-butyl-1,2-dihydroxybenzene have been synthesized, and their effect on radiation-induced free-radical oxidation of n-hexane and production of reactive oxygen and chlorine forms in neutrophils have been studied. It has been shown the introduction of the phenylhydrazone and phenylazomethine groups significantly increases the antioxidant activity of pyrocatechol derivatives. For six compounds, the ability to prevent the development of oxidative stress due to hyperproduction of active oxygen intermediates and HOCl/OCl− in neutrophils has been revealed.
作者简介
G. Ksendzova
Research Institute of Physical and Chemical Problems
Email: ksja-bn@tut.by
白俄罗斯, ul. Leningradskaya 14, Minsk, 220050
N. Ostrovskaya
Research Institute of Physical and Chemical Problems
Email: ksja-bn@tut.by
白俄罗斯, ul. Leningradskaya 14, Minsk, 220050
G. Semenkova
Belarusian State University
编辑信件的主要联系方式.
Email: ksja-bn@tut.by
白俄罗斯, Minsk
V. Sorokin
Belarusian State University
Email: ksja-bn@tut.by
白俄罗斯, Minsk
P. Shishkanova
Belarusian State University
Email: ksja-bn@tut.by
白俄罗斯, Minsk
O. Shadyro
Research Institute of Physical and Chemical Problems; Belarusian State University
Email: ksja-bn@tut.by
白俄罗斯, ul. Leningradskaya 14, Minsk, 220050; Minsk
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