Synthesis of 3,5-Di-tert-butyl-1,2-dihydroxybenzene Derivatives and Their Effect on Free-Radical Oxidation of Hexane and Oxygen Activation Ability of Neutrophils
- Authors: Ksendzova G.A.1, Ostrovskaya N.I.1, Semenkova G.N.2, Sorokin V.L.2, Shishkanova P.A.2, Shadyro O.I.1,2
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Affiliations:
- Research Institute of Physical and Chemical Problems
- Belarusian State University
- Issue: Vol 89, No 3 (2019)
- Pages: 391-398
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222778
- DOI: https://doi.org/10.1134/S1070363219030046
- ID: 222778
Cite item
Abstract
C6-Substituted derivatives of 3,5-di-tert-butyl-1,2-dihydroxybenzene have been synthesized, and their effect on radiation-induced free-radical oxidation of n-hexane and production of reactive oxygen and chlorine forms in neutrophils have been studied. It has been shown the introduction of the phenylhydrazone and phenylazomethine groups significantly increases the antioxidant activity of pyrocatechol derivatives. For six compounds, the ability to prevent the development of oxidative stress due to hyperproduction of active oxygen intermediates and HOCl/OCl− in neutrophils has been revealed.
About the authors
G. A. Ksendzova
Research Institute of Physical and Chemical Problems
Email: ksja-bn@tut.by
Belarus, ul. Leningradskaya 14, Minsk, 220050
N. I. Ostrovskaya
Research Institute of Physical and Chemical Problems
Email: ksja-bn@tut.by
Belarus, ul. Leningradskaya 14, Minsk, 220050
G. N. Semenkova
Belarusian State University
Author for correspondence.
Email: ksja-bn@tut.by
Belarus, Minsk
V. L. Sorokin
Belarusian State University
Email: ksja-bn@tut.by
Belarus, Minsk
P. A. Shishkanova
Belarusian State University
Email: ksja-bn@tut.by
Belarus, Minsk
O. I. Shadyro
Research Institute of Physical and Chemical Problems; Belarusian State University
Email: ksja-bn@tut.by
Belarus, ul. Leningradskaya 14, Minsk, 220050; Minsk