Synthesis of 3,5-Di-tert-butyl-1,2-dihydroxybenzene Derivatives and Their Effect on Free-Radical Oxidation of Hexane and Oxygen Activation Ability of Neutrophils
- Авторы: Ksendzova G.1, Ostrovskaya N.1, Semenkova G.2, Sorokin V.2, Shishkanova P.2, Shadyro O.1,2
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Учреждения:
- Research Institute of Physical and Chemical Problems
- Belarusian State University
- Выпуск: Том 89, № 3 (2019)
- Страницы: 391-398
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222778
- DOI: https://doi.org/10.1134/S1070363219030046
- ID: 222778
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Аннотация
C6-Substituted derivatives of 3,5-di-tert-butyl-1,2-dihydroxybenzene have been synthesized, and their effect on radiation-induced free-radical oxidation of n-hexane and production of reactive oxygen and chlorine forms in neutrophils have been studied. It has been shown the introduction of the phenylhydrazone and phenylazomethine groups significantly increases the antioxidant activity of pyrocatechol derivatives. For six compounds, the ability to prevent the development of oxidative stress due to hyperproduction of active oxygen intermediates and HOCl/OCl− in neutrophils has been revealed.
Об авторах
G. Ksendzova
Research Institute of Physical and Chemical Problems
Email: ksja-bn@tut.by
Белоруссия, ul. Leningradskaya 14, Minsk, 220050
N. Ostrovskaya
Research Institute of Physical and Chemical Problems
Email: ksja-bn@tut.by
Белоруссия, ul. Leningradskaya 14, Minsk, 220050
G. Semenkova
Belarusian State University
Автор, ответственный за переписку.
Email: ksja-bn@tut.by
Белоруссия, Minsk
V. Sorokin
Belarusian State University
Email: ksja-bn@tut.by
Белоруссия, Minsk
P. Shishkanova
Belarusian State University
Email: ksja-bn@tut.by
Белоруссия, Minsk
O. Shadyro
Research Institute of Physical and Chemical Problems; Belarusian State University
Email: ksja-bn@tut.by
Белоруссия, ul. Leningradskaya 14, Minsk, 220050; Minsk
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