Microwave-Assisted Synthesis of Novel Spirochromanone–Aurone Hybrids and Their Antimicrobial Activity

详细

New chromanone and aurone hybrids have been synthesized by conventional and microwave induced methods from substituted (E)-7-hydroxy-6-[3-(p-tolyl)acryloyl]spiro[chroman-2,1'-cyclohexan]-4-one with high yields. Structures of the synthesized compounds have been elucidated from IR, ¹H and ¹³C NMR, and mass spectra. All newly synthesized compounds were tested in vitro for their antimicrobial activity. Methoxysubstituted spirochromanones revealed the best antimicrobial profile.