Synthesis, biological evaluation, and molecular docking studies of diacylhydrazine derivatives possessing 1,4-benzodioxan moiety as potential anticancer agents
- 作者: Wang S.1, Liu H.1, Xu R.2, Sun J.1,3
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隶属关系:
- School of Life Sciences
- Shandong Experimental High School
- Elion Nature Biological Technology Co. Ltd
- 期: 卷 87, 编号 11 (2017)
- 页面: 2671-2677
- 栏目: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221614
- DOI: https://doi.org/10.1134/S1070363217110238
- ID: 221614
如何引用文章
详细
A series of diacylhydrazine derivatives containing 1,4-benzodioxan 1-17 has been designed, synthesized and evaluated for antitumor activity. Most of the synthesized compounds demonstrated potent antitumor activity and low toxicity. Compound 10 demonstrated the most potent biological activity against MCF-7 cancer cell line, which was comparable with the positive control 5-fluorouracil. Docking simulation by positioning compound 10 into the MetAP2 structure active site was performed to explore the possible binding model.
作者简介
S. Wang
School of Life Sciences
Email: sunreiyi86@163.com
中国, Zibo, 255049
H.-Y. Liu
School of Life Sciences
Email: sunreiyi86@163.com
中国, Zibo, 255049
R.-F. Xu
Shandong Experimental High School
Email: sunreiyi86@163.com
中国, Jinan, 250001
J. Sun
School of Life Sciences; Elion Nature Biological Technology Co. Ltd
编辑信件的主要联系方式.
Email: sunreiyi86@163.com
中国, Zibo, 255049; Nanjing, 210046