Synthesis, biological evaluation, and molecular docking studies of diacylhydrazine derivatives possessing 1,4-benzodioxan moiety as potential anticancer agents
- Authors: Wang S.1, Liu H.1, Xu R.2, Sun J.1,3
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Affiliations:
- School of Life Sciences
- Shandong Experimental High School
- Elion Nature Biological Technology Co. Ltd
- Issue: Vol 87, No 11 (2017)
- Pages: 2671-2677
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221614
- DOI: https://doi.org/10.1134/S1070363217110238
- ID: 221614
Cite item
Abstract
A series of diacylhydrazine derivatives containing 1,4-benzodioxan 1-17 has been designed, synthesized and evaluated for antitumor activity. Most of the synthesized compounds demonstrated potent antitumor activity and low toxicity. Compound 10 demonstrated the most potent biological activity against MCF-7 cancer cell line, which was comparable with the positive control 5-fluorouracil. Docking simulation by positioning compound 10 into the MetAP2 structure active site was performed to explore the possible binding model.
Keywords
About the authors
S. Wang
School of Life Sciences
Email: sunreiyi86@163.com
China, Zibo, 255049
H.-Y. Liu
School of Life Sciences
Email: sunreiyi86@163.com
China, Zibo, 255049
R.-F. Xu
Shandong Experimental High School
Email: sunreiyi86@163.com
China, Jinan, 250001
J. Sun
School of Life Sciences; Elion Nature Biological Technology Co. Ltd
Author for correspondence.
Email: sunreiyi86@163.com
China, Zibo, 255049; Nanjing, 210046