Synthesis, biological evaluation, and molecular docking studies of diacylhydrazine derivatives possessing 1,4-benzodioxan moiety as potential anticancer agents
- Авторы: Wang S.1, Liu H.1, Xu R.2, Sun J.1,3
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Учреждения:
- School of Life Sciences
- Shandong Experimental High School
- Elion Nature Biological Technology Co. Ltd
- Выпуск: Том 87, № 11 (2017)
- Страницы: 2671-2677
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221614
- DOI: https://doi.org/10.1134/S1070363217110238
- ID: 221614
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Аннотация
A series of diacylhydrazine derivatives containing 1,4-benzodioxan 1-17 has been designed, synthesized and evaluated for antitumor activity. Most of the synthesized compounds demonstrated potent antitumor activity and low toxicity. Compound 10 demonstrated the most potent biological activity against MCF-7 cancer cell line, which was comparable with the positive control 5-fluorouracil. Docking simulation by positioning compound 10 into the MetAP2 structure active site was performed to explore the possible binding model.
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Об авторах
S. Wang
School of Life Sciences
Email: sunreiyi86@163.com
Китай, Zibo, 255049
H.-Y. Liu
School of Life Sciences
Email: sunreiyi86@163.com
Китай, Zibo, 255049
R.-F. Xu
Shandong Experimental High School
Email: sunreiyi86@163.com
Китай, Jinan, 250001
J. Sun
School of Life Sciences; Elion Nature Biological Technology Co. Ltd
Автор, ответственный за переписку.
Email: sunreiyi86@163.com
Китай, Zibo, 255049; Nanjing, 210046