Synthesis of azamacrocyclic compounds by cyclocondensation of aliphatic α,ω-diamines with acetone

详细

Cyclocondensation of 1,4-diaminobutane and 1,6-diaminohexane with acetone afforded the corresponding 18- and 22-membered trans-azamacrocyclic Curtis compounds in high yield, which contain two azomethine and amine nitrogen atoms. A complex mixture of the products formed containing less than 25% of 16-membered azamacrocyclic cis- and trans-isomers when reacting 1,3-diaminopropane with acetone.