Synthesis of tetrahydroisoquinoline derivatives and evaluation of their anti-breast cancer activity

X. P. Zhang; F. J. Yu; X. W. Ding; X. M. He; D. H. Zou

doi:10.1134/S1070363216060311

Synthesis of tetrahydroisoquinoline derivatives and evaluation of their anti-breast cancer activity

作者: Zhang X.¹, Yu F.², Ding X.¹, He X.¹, Zou D.¹
隶属关系:
1. Department of Breast Tumor Surgery
2. Department of Medical Record Management
期: 卷 86, 编号 6 (2016)
页面: 1430-1433
栏目: Article
URL: https://journals.rcsi.science/1070-3632/article/view/215464
DOI: https://doi.org/10.1134/S1070363216060311
ID: 215464

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详细

Four novel tetrahydroisoquinoline derivatives 1–4 were synthesized and characterized by IR, ¹H NMR, HRMS, and single crystal X-ray crystallography. Anticancer effect of the products were studied on five human breast cancer cell lines including MDA-MB-231, MDA-MB-468, SK-BR-3, MCF7, HCC70 T4-2. Compounds 3 and 4 demonstrated higher activity than 1 and 2.