Synthesis of tetrahydroisoquinoline derivatives and evaluation of their anti-breast cancer activity

X. P. Zhang; F. J. Yu; X. W. Ding; X. M. He; D. H. Zou

doi:10.1134/S1070363216060311

Synthesis of tetrahydroisoquinoline derivatives and evaluation of their anti-breast cancer activity

Авторлар: Zhang X.¹, Yu F.², Ding X.¹, He X.¹, Zou D.¹
Мекемелер:
1. Department of Breast Tumor Surgery
2. Department of Medical Record Management
Шығарылым: Том 86, № 6 (2016)
Беттер: 1430-1433
Бөлім: Article
URL: https://journals.rcsi.science/1070-3632/article/view/215464
DOI: https://doi.org/10.1134/S1070363216060311
ID: 215464

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат
Рұқсат жабық

Рұқсат берілді
Рұқсат жабық

Тек жазылушылар үшін

Аннотация
Авторлар туралы
Әдебиет тізімі
Статистика

Аннотация

Four novel tetrahydroisoquinoline derivatives 1–4 were synthesized and characterized by IR, ¹H NMR, HRMS, and single crystal X-ray crystallography. Anticancer effect of the products were studied on five human breast cancer cell lines including MDA-MB-231, MDA-MB-468, SK-BR-3, MCF7, HCC70 T4-2. Compounds 3 and 4 demonstrated higher activity than 1 and 2.