Отправить статью по E-mail Design, Synthesis and Anticancer Activity of 1,2,4-Thiadiazole Derivatives Bearing 1,2,4-Oxadiazole
- Авторы: Sudhakar D.1,2, Rao A.1, Reddy C.2
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Учреждения:
- Medicinal Chemistry Division
- Department of Chemistry
- Выпуск: Том 89, № 8 (2019)
- Страницы: 1696-1701
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223048
- DOI: https://doi.org/10.1134/S1070363219080243
- ID: 223048
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Аннотация
A series of novel 1,2,4-thiadiazole derivatives bearing 1,2,4-oxadiazole is synthesized. Structures of the synthesized compounds are confirmed by 1H and 13C NMR, and mass spectra. All products are evaluated for their anticancer activity towards human cancer cell lines: MCF-7 (breast), A549 (lung), Colo-205 (colon), and A2780 (ovarian), and demonstrate good to moderate anticancer activity. Four synthesized compounds are characterised by potent activity.
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Об авторах
D. Sudhakar
Medicinal Chemistry Division; Department of Chemistry
Автор, ответственный за переписку.
Email: sudhakardgs1org@outlook.com
Индия, 28A, Nacharam, IDA-Mallapur, Hyderabad, Telangana, 500076; Hyderabad, Telangana, 500085
A. Rao
Medicinal Chemistry Division
Email: sudhakardgs1org@outlook.com
Индия, 28A, Nacharam, IDA-Mallapur, Hyderabad, Telangana, 500076
Ch. Reddy
Department of Chemistry
Email: sudhakardgs1org@outlook.com
Индия, Hyderabad, Telangana, 500085
