Synthesis and Anticancer Activity of New Substituted Piperidinones Linked to Pyrimidine, Thiazole, and Triazole Glycoside Derivatives
- Авторы: Yousif M.1, Nassar I.2, Yousif N.1, Awad H.3, El-Sayed W.1,4
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Учреждения:
- Photochemistry Department
- Faculty of Specific Education
- Tanning Materials and Leather Technology Department
- Chemistry Department, Faculty of Science
- Выпуск: Том 89, № 8 (2019)
- Страницы: 1673-1682
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223043
- DOI: https://doi.org/10.1134/S1070363219080218
- ID: 223043
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Аннотация
New piperidinone incorporating pyrimidine, triazine, diazipine, oxatriazine, and thiazole derivatives have been synthesized starting with tetramethylpipridin-4-one. Structures of the newly synthesized compounds are characterized on the basis of spectroscopic and analytical data. The anticancer activity of the prepared compounds has been studied in vitro against HCT-116 and MCF-7 human cancer cells using the MTT assay. A number of compounds demonstrates potent activity towards both cell lines with IC50 values comparable with doxorubicin.
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Об авторах
M. Yousif
Photochemistry Department
Автор, ответственный за переписку.
Email: mahmoud_nabil18@yahoo.com
Египет, Cairo
I. Nassar
Faculty of Specific Education
Email: waelshendy@gmail.com
Египет, Cairo
N. Yousif
Photochemistry Department
Email: waelshendy@gmail.com
Египет, Cairo
H. Awad
Tanning Materials and Leather Technology Department
Email: waelshendy@gmail.com
Египет, El-Behouth St, Dokki, Cairo
W. El-Sayed
Photochemistry Department; Chemistry Department, Faculty of Science
Автор, ответственный за переписку.
Email: waelshendy@gmail.com
Египет, Cairo; Buraydah
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