Synthesis and Anticancer Activity of New Substituted Piperidinones Linked to Pyrimidine, Thiazole, and Triazole Glycoside Derivatives
- Autores: Yousif M.1, Nassar I.2, Yousif N.1, Awad H.3, El-Sayed W.1,4
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Afiliações:
- Photochemistry Department
- Faculty of Specific Education
- Tanning Materials and Leather Technology Department
- Chemistry Department, Faculty of Science
- Edição: Volume 89, Nº 8 (2019)
- Páginas: 1673-1682
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223043
- DOI: https://doi.org/10.1134/S1070363219080218
- ID: 223043
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Resumo
New piperidinone incorporating pyrimidine, triazine, diazipine, oxatriazine, and thiazole derivatives have been synthesized starting with tetramethylpipridin-4-one. Structures of the newly synthesized compounds are characterized on the basis of spectroscopic and analytical data. The anticancer activity of the prepared compounds has been studied in vitro against HCT-116 and MCF-7 human cancer cells using the MTT assay. A number of compounds demonstrates potent activity towards both cell lines with IC50 values comparable with doxorubicin.
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Sobre autores
M. Yousif
Photochemistry Department
Autor responsável pela correspondência
Email: mahmoud_nabil18@yahoo.com
Egito, Cairo
I. Nassar
Faculty of Specific Education
Email: waelshendy@gmail.com
Egito, Cairo
N. Yousif
Photochemistry Department
Email: waelshendy@gmail.com
Egito, Cairo
H. Awad
Tanning Materials and Leather Technology Department
Email: waelshendy@gmail.com
Egito, El-Behouth St, Dokki, Cairo
W. El-Sayed
Photochemistry Department; Chemistry Department, Faculty of Science
Autor responsável pela correspondência
Email: waelshendy@gmail.com
Egito, Cairo; Buraydah
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