Email this article Synthesis and Anticancer Activity of New Substituted Piperidinones Linked to Pyrimidine, Thiazole, and Triazole Glycoside Derivatives
- Authors: Yousif M.N.1, Nassar I.F.2, Yousif N.M.1, Awad H.M.3, El-Sayed W.A.1,4
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Affiliations:
- Photochemistry Department
- Faculty of Specific Education
- Tanning Materials and Leather Technology Department
- Chemistry Department, Faculty of Science
- Issue: Vol 89, No 8 (2019)
- Pages: 1673-1682
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/223043
- DOI: https://doi.org/10.1134/S1070363219080218
- ID: 223043
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Abstract
New piperidinone incorporating pyrimidine, triazine, diazipine, oxatriazine, and thiazole derivatives have been synthesized starting with tetramethylpipridin-4-one. Structures of the newly synthesized compounds are characterized on the basis of spectroscopic and analytical data. The anticancer activity of the prepared compounds has been studied in vitro against HCT-116 and MCF-7 human cancer cells using the MTT assay. A number of compounds demonstrates potent activity towards both cell lines with IC50 values comparable with doxorubicin.
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About the authors
M. N. M. Yousif
Photochemistry Department
Author for correspondence.
Email: mahmoud_nabil18@yahoo.com
Egypt, Cairo
I. F. Nassar
Faculty of Specific Education
Email: waelshendy@gmail.com
Egypt, Cairo
N. M. Yousif
Photochemistry Department
Email: waelshendy@gmail.com
Egypt, Cairo
H. M. Awad
Tanning Materials and Leather Technology Department
Email: waelshendy@gmail.com
Egypt, El-Behouth St, Dokki, Cairo
W. A. El-Sayed
Photochemistry Department; Chemistry Department, Faculty of Science
Author for correspondence.
Email: waelshendy@gmail.com
Egypt, Cairo; Buraydah
