Отправить статью по E-mail Synthesis of New Substituted 1,2,4-Triazoles and 1,3,4-Thiadiazoles and Their Effects on DNA Methylation Level
- Авторы: Hovsepyan T.1, Hakobyan M.1, Muradyan R.1, Nersesyan L.1, Agaronyan A.1, Danielyan I.1, Minasyan N.2
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Учреждения:
- A.L. Mndzhoyan Institute of Fine Organic Chemistry of the Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
- Molecular Structure Research Center of the Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences
- Выпуск: Том 89, № 4 (2019)
- Страницы: 673-679
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222848
- DOI: https://doi.org/10.1134/S1070363219040066
- ID: 222848
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Аннотация
Continuing the search for biologically active compounds among functionally substituted azoles, new 1,2,4-triazole-3-thiols and 1,3,4-thiadiazoles derivatives bearing pharmacologically active carboxamide, hydroxyl or carboxyalkyl moieties, as well as N-acyclonucleoside, N-cyano- or carboxyethyl fragments were synthesized. Ability of some compounds obtained to inhibit the methylation of tumor DNA in vitro was revealed. The compound with the highest activity was selected for further in vivo studies.
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Об авторах
T. Hovsepyan
A.L. Mndzhoyan Institute of Fine Organic Chemistry of the Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Автор, ответственный за переписку.
Email: tag.hovsepyan@mail.ru
Армения, pr. Azatutyan 26, Yerevan, 0014
M. Hakobyan
A.L. Mndzhoyan Institute of Fine Organic Chemistry of the Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: tag.hovsepyan@mail.ru
Армения, pr. Azatutyan 26, Yerevan, 0014
R. Muradyan
A.L. Mndzhoyan Institute of Fine Organic Chemistry of the Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: tag.hovsepyan@mail.ru
Армения, pr. Azatutyan 26, Yerevan, 0014
L. Nersesyan
A.L. Mndzhoyan Institute of Fine Organic Chemistry of the Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: tag.hovsepyan@mail.ru
Армения, pr. Azatutyan 26, Yerevan, 0014
A. Agaronyan
A.L. Mndzhoyan Institute of Fine Organic Chemistry of the Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: tag.hovsepyan@mail.ru
Армения, pr. Azatutyan 26, Yerevan, 0014
I. Danielyan
A.L. Mndzhoyan Institute of Fine Organic Chemistry of the Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: tag.hovsepyan@mail.ru
Армения, pr. Azatutyan 26, Yerevan, 0014
N. Minasyan
Molecular Structure Research Center of the Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences
Email: tag.hovsepyan@mail.ru
Армения, Yerevan
