Synthesis of New Substituted 1,2,4-Triazoles and 1,3,4-Thiadiazoles and Their Effects on DNA Methylation Level

详细

Continuing the search for biologically active compounds among functionally substituted azoles, new 1,2,4-triazole-3-thiols and 1,3,4-thiadiazoles derivatives bearing pharmacologically active carboxamide, hydroxyl or carboxyalkyl moieties, as well as N-acyclonucleoside, N-cyano- or carboxyethyl fragments were synthesized. Ability of some compounds obtained to inhibit the methylation of tumor DNA in vitro was revealed. The compound with the highest activity was selected for further in vivo studies.