Email this article Synthesis of New Substituted 1,2,4-Triazoles and 1,3,4-Thiadiazoles and Their Effects on DNA Methylation Level
- Authors: Hovsepyan T.R.1, Hakobyan M.R.1, Muradyan R.E.1, Nersesyan L.E.1, Agaronyan A.S.1, Danielyan I.S.1, Minasyan N.S.2
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Affiliations:
- A.L. Mndzhoyan Institute of Fine Organic Chemistry of the Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
- Molecular Structure Research Center of the Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences
- Issue: Vol 89, No 4 (2019)
- Pages: 673-679
- Section: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222848
- DOI: https://doi.org/10.1134/S1070363219040066
- ID: 222848
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Abstract
Continuing the search for biologically active compounds among functionally substituted azoles, new 1,2,4-triazole-3-thiols and 1,3,4-thiadiazoles derivatives bearing pharmacologically active carboxamide, hydroxyl or carboxyalkyl moieties, as well as N-acyclonucleoside, N-cyano- or carboxyethyl fragments were synthesized. Ability of some compounds obtained to inhibit the methylation of tumor DNA in vitro was revealed. The compound with the highest activity was selected for further in vivo studies.
About the authors
T. R. Hovsepyan
A.L. Mndzhoyan Institute of Fine Organic Chemistry of the Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Author for correspondence.
Email: tag.hovsepyan@mail.ru
Armenia, pr. Azatutyan 26, Yerevan, 0014
M. R. Hakobyan
A.L. Mndzhoyan Institute of Fine Organic Chemistry of the Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: tag.hovsepyan@mail.ru
Armenia, pr. Azatutyan 26, Yerevan, 0014
R. E. Muradyan
A.L. Mndzhoyan Institute of Fine Organic Chemistry of the Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: tag.hovsepyan@mail.ru
Armenia, pr. Azatutyan 26, Yerevan, 0014
L. E. Nersesyan
A.L. Mndzhoyan Institute of Fine Organic Chemistry of the Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: tag.hovsepyan@mail.ru
Armenia, pr. Azatutyan 26, Yerevan, 0014
A. S. Agaronyan
A.L. Mndzhoyan Institute of Fine Organic Chemistry of the Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: tag.hovsepyan@mail.ru
Armenia, pr. Azatutyan 26, Yerevan, 0014
I. S. Danielyan
A.L. Mndzhoyan Institute of Fine Organic Chemistry of the Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: tag.hovsepyan@mail.ru
Armenia, pr. Azatutyan 26, Yerevan, 0014
N. S. Minasyan
Molecular Structure Research Center of the Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences
Email: tag.hovsepyan@mail.ru
Armenia, Yerevan
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