Synthesis and Anticancer Activity of 1,2,4-Oxadiazole Fused Benzofuran Derivatives
- Авторы: Pervaram S.1, Ashok D.2, Sarasija M.1, Reddy C.1, Sridhar G.3
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Учреждения:
- Department of Chemistry
- Green and Medicinal Chemistry Laboratory, Department of Chemistry
- Organic and Biomolecular Chemistry Division
- Выпуск: Том 88, № 6 (2018)
- Страницы: 1219-1223
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222263
- DOI: https://doi.org/10.1134/S1070363218060282
- ID: 222263
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Аннотация
Ten 1,2,4-oxadiazole fused benzofuran derivatives 11a–11j are synthesized, and their structures are confirmed by 1H and 13C NMR, and mass spectral data. Their anticancer activity against four human cancer cell lines, A549 (Lung), MCF7 (Breast), A375 (Melanoma), and HT-29 (Colon), by the MTT method is tested. The compounds 11b–11d, 11g, 11h, and 11j demonstrate more potent activity than the positive control.
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Об авторах
S. Pervaram
Department of Chemistry
Автор, ответственный за переписку.
Email: pervaramsridhar@gmail.com
Индия, Hyderabad, Telangana, 500085
D. Ashok
Green and Medicinal Chemistry Laboratory, Department of Chemistry
Email: pervaramsridhar@gmail.com
Индия, Hyderabad, Telangana, 500007
M. Sarasija
Department of Chemistry
Email: pervaramsridhar@gmail.com
Индия, Karimnagar, Telangana, 505001
C. Reddy
Department of Chemistry
Email: pervaramsridhar@gmail.com
Индия, Hyderabad, Telangana, 500085
G. Sridhar
Organic and Biomolecular Chemistry Division
Email: pervaramsridhar@gmail.com
Индия, Hyderabad, 500007
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