Synthesis and Anticancer Activity of 1,2,4-Oxadiazole Fused Benzofuran Derivatives

S. Pervaram; D. Ashok; M. Sarasija; C. V. R. Reddy; G. Sridhar

doi:10.1134/S1070363218060282

Synthesis and Anticancer Activity of 1,2,4-Oxadiazole Fused Benzofuran Derivatives

作者: Pervaram S.¹, Ashok D.², Sarasija M.¹, Reddy C.¹, Sridhar G.³
隶属关系:
1. Department of Chemistry
2. Green and Medicinal Chemistry Laboratory, Department of Chemistry
3. Organic and Biomolecular Chemistry Division
期: 卷 88, 编号 6 (2018)
页面: 1219-1223
栏目: Article
URL: https://journals.rcsi.science/1070-3632/article/view/222263
DOI: https://doi.org/10.1134/S1070363218060282
ID: 222263

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详细

Ten 1,2,4-oxadiazole fused benzofuran derivatives 11a–11j are synthesized, and their structures are confirmed by ¹H and ¹³C NMR, and mass spectral data. Their anticancer activity against four human cancer cell lines, A549 (Lung), MCF7 (Breast), A375 (Melanoma), and HT-29 (Colon), by the MTT method is tested. The compounds 11b–11d, 11g, 11h, and 11j demonstrate more potent activity than the positive control.