Enviar artigo por via de e-mail Synthesis and Anticancer Activity of 1,2,4-Oxadiazole Fused Benzofuran Derivatives
- Autores: Pervaram S.1, Ashok D.2, Sarasija M.1, Reddy C.1, Sridhar G.3
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Afiliações:
- Department of Chemistry
- Green and Medicinal Chemistry Laboratory, Department of Chemistry
- Organic and Biomolecular Chemistry Division
- Edição: Volume 88, Nº 6 (2018)
- Páginas: 1219-1223
- Seção: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/222263
- DOI: https://doi.org/10.1134/S1070363218060282
- ID: 222263
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Resumo
Ten 1,2,4-oxadiazole fused benzofuran derivatives 11a–11j are synthesized, and their structures are confirmed by 1H and 13C NMR, and mass spectral data. Their anticancer activity against four human cancer cell lines, A549 (Lung), MCF7 (Breast), A375 (Melanoma), and HT-29 (Colon), by the MTT method is tested. The compounds 11b–11d, 11g, 11h, and 11j demonstrate more potent activity than the positive control.
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Sobre autores
S. Pervaram
Department of Chemistry
Autor responsável pela correspondência
Email: pervaramsridhar@gmail.com
Índia, Hyderabad, Telangana, 500085
D. Ashok
Green and Medicinal Chemistry Laboratory, Department of Chemistry
Email: pervaramsridhar@gmail.com
Índia, Hyderabad, Telangana, 500007
M. Sarasija
Department of Chemistry
Email: pervaramsridhar@gmail.com
Índia, Karimnagar, Telangana, 505001
C. Reddy
Department of Chemistry
Email: pervaramsridhar@gmail.com
Índia, Hyderabad, Telangana, 500085
G. Sridhar
Organic and Biomolecular Chemistry Division
Email: pervaramsridhar@gmail.com
Índia, Hyderabad, 500007
