Simple and efficient method for aromatization of tetrahydro-β-carbolines by using K2S2O8 as a catalyst and its antimicrobial activity comparison with molecular docking studies
- Авторы: Kurumanna A.1, Ashok K.1, Rambabu S.1, Sonyanaik B.1, Ravi D.1, Madhu P.1, Sakram B.1
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Учреждения:
- Department of Chemistry
- Выпуск: Том 87, № 11 (2017)
- Страницы: 2703-2711
- Раздел: Article
- URL: https://journals.rcsi.science/1070-3632/article/view/221634
- DOI: https://doi.org/10.1134/S1070363217110287
- ID: 221634
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Аннотация
A novel and efficient aromatization of tetrahydro-β-carbolines under mild conditions using K2S2O8 as a catalyst was developed. The method is applicable for all kinds of C1 substituted systems. All synthesized compounds were screened for their in vitro antibacterial activity against Staphylococus aureus, Bacillus subtilis, Escherichia coli, and Klebsiella pneumonia, as well as fungi, such as Aspergillus flavus and Fusarium oxysporum. Compounds 4b, 4g, 4i, and 4k demonstrated excellent in vitro antibacterial and antifungal activities than the standard drugs. The docking studies were carried out for most active compounds 4b, 4g, 4i, and 4k.
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Об авторах
A. Kurumanna
Department of Chemistry
Email: bschemou@gmail.com
Индия, Tarnaka, Hyderabad, Telangana, 500007
K. Ashok
Department of Chemistry
Email: bschemou@gmail.com
Индия, Tarnaka, Hyderabad, Telangana, 500007
S. Rambabu
Department of Chemistry
Email: bschemou@gmail.com
Индия, Tarnaka, Hyderabad, Telangana, 500007
B. Sonyanaik
Department of Chemistry
Email: bschemou@gmail.com
Индия, Tarnaka, Hyderabad, Telangana, 500007
D. Ravi
Department of Chemistry
Email: bschemou@gmail.com
Индия, Tarnaka, Hyderabad, Telangana, 500007
P. Madhu
Department of Chemistry
Email: bschemou@gmail.com
Индия, Tarnaka, Hyderabad, Telangana, 500007
B. Sakram
Department of Chemistry
Автор, ответственный за переписку.
Email: bschemou@gmail.com
Индия, Tarnaka, Hyderabad, Telangana, 500007